Open Access

Multiple congenital oral granular cell tumours in a newborn black female: a case report

  • Liviu Feller1Email author,
  • Neil H Wood1,
  • Avin S Singh2,
  • Erich J Raubenheimer3,
  • Robin Meyerov1 and
  • Johan Lemmer4, 5
Cases Journal20081:13

DOI: 10.1186/1757-1626-1-13

Received: 24 April 2008

Accepted: 30 May 2008

Published: 30 May 2008

Abstract

Introduction

Congenital oral granular cell tumour of the newborn is an uncommon benign tumour of uncertain origin. The typical clinical appearance is of a single nodule occurring on the anterior maxillary ridge. In 10% of cases there are multiple lesions. The occurrence of congenital epulis in non-Caucasians is rare.

Case presentation

Two firm pedunculated nodular lesions were noticed in the mouth of a 3-day-old black female: one on the anterior maxillary ridge and the other further posteriorly in the midline of the palate. Both lesions were excised when the baby was nine days old. Microscopic examination of the lesions showed densely packed round to oval cells with abundant granular eosinophilic cytoplasm and uniform nuclei. The diagnosis was congenital granular cell tumour.

Conclusion

Congenital oral granular cell tumour occurs almost exclusively in Caucasian newborns but also rarely in black infants. The parents should be assured of the benign nature and the simple treatment of the condition.

Introduction

Congenital epulis is an uncommon benign gingival tumour of the newborn. Although the condition has been well reported in the literature, to our knowledge this is the first case to be reported in a black South African infant.

Epulis is a non-specific term connoting a tumour-like mass of the gingiva and the term is used in association with several different gingival lesions, regardless of their aetiology or histogenesis [1]. Since a lesion identical to congenital epulis may occur on the tongue, the term congenital epulis should be discontinued and the term congenital granular cell tumour be used instead [2, 3].

Case presentation and discussion

Three days after the birth of a black female, two lumps were noticed in her mouth. No other oral abnormalities were noted. The lumps did not interfere with feeding or breathing. The mother was HIV-seropositive and had been receiving Neveripine since before the pregnancy. The mother would not allow the HIV-serostatus of the baby to be investigated.

On examination there were two firm pedunculated nodular lesions (Fig 1), one on the anterior maxillary ridge, 7.5 × 5 mm in size, and the other further posteriorly in the middle of the palate, 6.5 × 5 mm in size (Fig's 2A and 2B).
https://static-content.springer.com/image/art%3A10.1186%2F1757-1626-1-13/MediaObjects/13257_2008_Article_11_Fig1_HTML.jpg
Figure 1

Intraoral photograph showing two lesions: one on the anterior maxillary ridge and another on the middle of the palate.

https://static-content.springer.com/image/art%3A10.1186%2F1757-1626-1-13/MediaObjects/13257_2008_Article_11_Fig2_HTML.jpg
Figure 2

Both lesions were firm, pedunculated and encapsulated.

The differential diagnosis included congenital granular cell tumour (CGCT), odontogenic tumour, teratoma, neuroectodermal tumour, haemangioma and fibroma with a provisional diagnosis of CGCT. Both lesions were excised under general anaesthesia when the baby was 9 days old. Post-operative healing was uneventful.

Microscopic examination of the lesions showed round or ovoid cells with granular eosinophilic cytoplasm and centrally located nuclei (Fig 3). The masses were covered with a thin stratified squamous epithelium. The definitive diagnosis was CGCT.
https://static-content.springer.com/image/art%3A10.1186%2F1757-1626-1-13/MediaObjects/13257_2008_Article_11_Fig3_HTML.jpg
Figure 3

Densely packed round to oval cells with abundant granular eosinophilic cytoplasm and uniform nuclei. Note the thin walled blood vessel in the centre of the field (H&E stain ×200).

CGCT is uncommon and occurs almost exclusively in Caucasian newborns [1]. It is a well defined pedunculated nodule or mass, with a smooth or lobulated surface and is most frequently located on the masticatory mucosa of the maxillary alveolar process. The male to female ratio is 1:8 [4, 5]. CGCT can vary in size from several millimeters to several centimeters. Only 10% of subjects with CGCT present with multiple lesions that may affect one or both jaws [2, 3]. The condition is not associated with any other congenital abnormalities. Large lesions may interfere with breathing and with feeding [5]. Other than the gingiva, the tongue is the only site rarely affected by CGCT [2, 3].

CGCT occurs only in the newborn and is a distinct pathological entity [6]. It may be identified by prenatal sonography, but the findings are not specific and the ultrasonic differential diagnosis would include congenital malformations and various benign or malignant tumours [4].

Local excision is curative. If left untreated malignant transformation never occurs. Spontaneous regression of untreated lesions has been reported [1, 3, 5, 7]. CGCT appears to be more hamartomatous than neoplastic [1, 2].

The histogenesis of CGCT is obscure. Its possible origin may be odontogenic, fibroblastic, histiocytic, myogenic or neurogenic cells [15, 7], or perhaps pluripotential precursors of these cells. The reason for the development only on the alveolar masticatory mucosa or on the tongue remains unexplained [2, 3, 68].

Microscopically, CGCT typically consists of large closely packed polygonal cells with clear granular eosinophilic cytoplasm and centrally positioned nuclei, within a vascular fibrous connective tissue stroma, covered with squamous cell epithelium [110]. The granular cells stain positively for vimentin and negatively for S100-protein, oestrogen and progesterone receptors [5, 6]. Electron microscopic examination of the granular cells of CGCT shows heterogeneous electron-dense granules, lysosomes, and cytoplasmic lipid droplets [6]. CGCT and granular cell tumour found only in older people have similar microscopic features. However, the latter is less vascular and is typically covered by hyperplastic squamous cell epithelium [1, 4].

Conclusion

CGCT is relatively common in Caucasia newborns but appears to be much less common in black newborns, and the occurrence of more than one lesion in a black infant is rare. The family of an infant with CGCT should be assured of the benign nature and the simple treatment of the condition.

Consent

Written informed consent was obtained from the parent of the patient for the publication of this case report and for the use of images. A copy of the written consent is available for the Editor-in-Chief of this journal.

Declarations

Authors’ Affiliations

(1)
Department of Periodontology and Oral Medicine, School of Dentistry, Medunsa Campus, University of Limpopo
(2)
Department of Maxillofacial and Oral Surgery, School of Dentistry, Medunsa Campus, University of Limpopo
(3)
Department of Oral Pathology, School of Dentistry, Medunsa Campus, University of Limpopo
(4)
Department of Periodontology and Oral Medicine, School of Dentistry, Medunsa Campus, University of Limpopo
(5)
Professor Emeritus: Department of Oral Medicine and Periodontology, School of Dentistry, University of the Witwatersrand

References

  1. Anderson PJ, Kirkland P, Schafler K, Moss AL: Congenital gingival granular cell tumour. J R Soc Med. 1996, 89: 53P-54P.PubMed CentralPubMedGoogle Scholar
  2. Loyola Am, Gatti AF, Pinto S, Mesquita AA: Alveolar and extra-alveolar granular cell lesions of the newborn: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997, 84: 668-71. 10.1016/S1079-2104(97)90370-X.View ArticlePubMedGoogle Scholar
  3. Yavuzer R, Ataoglu O, Sari A: Multiple congenital epulis of the alveolar ridge and tongue. Ann Plast Surg. 2001, 47: 199-202. 10.1097/00000637-200108000-00017.View ArticlePubMedGoogle Scholar
  4. Koch BL, Myer C, Egelhoff JC: Congenital epulis. AJNR Am J Neuroradiol. 1997, 18: 739-741.PubMedGoogle Scholar
  5. Kannan SK, Rajesh R: Congenital epulis – congenital granular cell lesion: a case report. J Indian Soc Pedod Prev Dent. 2006, 24: 104-106.View ArticlePubMedGoogle Scholar
  6. Lapid O, Shaco-Levy R, Krieger Y, Kachko L, Sagi A: Congenital Epulis. Pediatrics. 2001, 107: E22-10.1542/peds.107.2.e22.View ArticlePubMedGoogle Scholar
  7. Olson JL, Marcus JR, Zuker RM: Congenital epulis. J Craniofac Surg. 2005, 16: 161-164. 10.1097/00001665-200501000-00033.View ArticlePubMedGoogle Scholar
  8. Lōpez de Lacalle JM, Aguirre I, Irizabal JC, Nogues A: Congenital epulis: prenatal diagnosis by ultrasound. Pediatr Radiol. 2001, 31: 453-454. 10.1007/s002470000416.View ArticlePubMedGoogle Scholar
  9. Kaiserling E, Ruck P, Xiao JC: Congenital Epulis and granular cell tumour. A histologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995, 80: 687-697. 10.1016/S1079-2104(05)80253-7.View ArticlePubMedGoogle Scholar
  10. Dash JK, Sahoo PK, Das SN: Congenital granular cell lesion "congenital epulis" – report of a case. J Indian Soc Pedod Prev Dent. 2004, 22: 63-67.PubMedGoogle Scholar

Copyright

© Feller et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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