Granular cell tumour of the pectoral muscle mimicking breast cancer
© Patel et al; licensee BioMed Central Ltd. 2008
Received: 21 August 2008
Accepted: 06 September 2008
Published: 06 September 2008
We describe the case of a 55 year old female who presented with a mass in her right breast. Mammography confirmed a 2 × 2 cm lump, suspicious of malignancy. The lesion was widely resected. Histological examination revealed this to be a benign granular cell tumour.
Granular cell tumour is a rare tumour that very occasionally presents within the breast. It is possibly of Schwann cell origin. Clinical features and subsequent investigations may be suggestive of breast malignancy. Tumour cells showing positive immunostaining for S-100 and PAS is in keeping with the diagnosis. Wide local resection is the gold standard treatment.
Granular cell tumour (GCT) was first described in 1926 by Abrikosoff as a rare myogenic lesion affecting the tongue. Further immunohistochemical tests have subsequently shown this lesion to have probably a perineural or Schwann cell origin. Abrikosoff in 1931 described a similar lesion in the female breast . GCT of the breast is relatively uncommon and very easily misdiagnosed for primary breast cancer. We present a case of GCT of the pectoral muscle mimicking breast cancer in a female patient, highlighting the diagnostic challenge and the treatment options in managing patients with GCT.
Microscopically the specimen consisted of a central area containing cells with finely granular eosinophillic cytoplasm containing central bland nuclei. Immuno-histochemistry staining showed tumour cells were positive for S 100 and weakly cytopositive for PAS, in keeping with a diagnosis of granular cell tumour. The tumour was completely excised. The patient remains well 6 months after surgery.
GCT is a rare usually benign tumour which is most frequently encountered in the tongue, but can occur in a variety of visceral and cutaneous sites. Although there are a limited number of reported cases in the English literature the frequency of GCT is estimated to be 1 per 1000 cases of breast cancer . It is more common in middle age, pre-menopausal, black women. Breast GCT in male patients is extremely rare. The preponderance of these tumours in women, especially premenopausal, has led to the hypothesis that hormones are implicated in the pathogenesis of these tumours in the breast, however, up to date, no oestrogen or progesterone receptors have been found on the tumour cells in any of the cases so far reported in the literature. GCT of the breast arises from interlobular breast stroma and affects predominantly the upper inner quadrants of the breast, in the territory of distribution of the cutaneous sensory branches of the supraclavicular nerve. GCT of the breast are usually benign but malignant cases have been described including 2 cases of GCT and infiltrating breast cancer within the same breast [3, 4].
GCT can closely resemble primary breast malignancies both clinically, due to their fibrous consistency, and radiologically. They present as hard lump which grow in an infiltrative manner and can involve the skin, causing skin dimpling and tethering, and the underlying muscle causing fixity of the lump to the deeper structures. Misdiagnosis could potentially lead to a far more aggressive treatment then necessary, hence it is important to differentiate GCT from other primary breast tumours. The final diagnosis is generally always achieved through histological examination.
Mammographic and sonographic appearance of GCT could be misleading. On mammograms GCT could present as round, well circumscribed masses, but also as indistinct densities or speculated masses which resemble primary breast carcinoma. Microcalcifications can sometimes be seen but are usually absent. The ultrasound appearances are also variable and include solid masses with indistinct margins or more benign-appearing, well circumscribed masses. Yang et al  has described the sonographic features of a series of 7 GCT of the breast and has interestingly shown that five of these lesions had an echogenic halo or were partially hyperechoic, this may be a result of the infiltrative growth pattern of GCT. In our case, sonographically the lesion was an ill defined hypoechoic mass with mild acoustic shadowing.
MRI scanning has proved to have additional diagnostic value in the detection of such lesions in the breast. It helps delineating the extent of the disease, the presence of aggressive features and is also valuable for concomitant screening of the controlateral breast. Kohashi et al  described a homogenously enhancing mass on T1 weighted imaging, the same mass showed high signal intensity rim on T2 weighted sequence. High T2 signal has been shown to be a sign of benign disease . Features suggestive of malignancy include rim enhancement, speculated margins and irregular ill-defined shape of the breast lesion. Interestingly microcalcifications have been absent in every case of GCT reviewed so far and their presence should point towards a malignancy other then GCT .
For GCT which have been proven to be benign at core biopsy close observation is an acceptable treatment option although wide local excision is regarded as gold standard in the treatment of benign GCT. Local recurrence is associated with incomplete excision hence a complete clearance of the tumours with histologically clear margins is paramount. Axillary sampling or sentinel lymph node biopsy is not indicated  in the management of benign GCT as nodal invasion is extremely rare. Malignant GCT should be treated like other malignant breast tumours, however treatment has a poor overall outcome .
Differentiation between benign and malignant breast GCT is almost impossible on the clinical basis, and remains challenging even after accurate histological study of the specimen. High index of suspicion is therefore paramount, especially in presence of a breast mass with associated axillary lymphadenopathy, or if the breast lesion is larger then 4 cm in diameter on radiological imaging. On MRI evidence of infiltration of adjacent tissues and rim enhancement are also regarded as suspicious features.
In conclusion, as GCT can easily be misdiagnosed as primary breast carcinoma clinically and radiologically, histological analysis of these lesions is needed to achieve a diagnosis. This case highlights the benefits of triple assessment in the management of beast lumps Surgeons should always be aware that GCT of the breast can resemble primary breast tumour in order to avoid performing unnecessary radical surgery in this group of patients.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Abrikosoff A: "Weitere untersuchungen uber mublastenmyome". Virchow Arch Path Anat. 1931, 280: 723-10.1007/BF02038883.View ArticleGoogle Scholar
- Gordon AB, Fisher C, Palmer B, Greening WP: Granular cell tumour of the breast. Eur J Surg Oncol. 1985, 11 (3): 269-73.PubMedGoogle Scholar
- Tran TA, Kallakury BV, Carter J, Wolf BC, Ross JS: Coexistence of granular cell tumor and ipsilateral infiltrating ductal carcinoma of the breast. South Med J. 1997, 90 (11): 1149-51. 10.1097/00007611-199711000-00020.View ArticlePubMedGoogle Scholar
- Al-Ahmadie H, Hasselgren PO, Yassin R, Mutema G: Colocalized granular cell tumor and infiltrating ductal carcinoma of the breast. Arch Pathol Lab Med. 2002, 126 (6): 731-3.PubMedGoogle Scholar
- Regalado J, Sittler S: GGT of the male breast: a report of 3 cases and a review of the literature. Breast Dis. 1996, 9: 235.Google Scholar
- Yang WT, Edeiken-Monroe B, Sneige N, Fornage BD: Sonographic and mammographic appearances of granular cell tumors of the breast with pathological correlation. J Clin Ultrasound. 2006, 34 (4): 153-60. 10.1002/jcu.20227.View ArticlePubMedGoogle Scholar
- Kohashi T, Kataoka T, Haruta R, Sugino K, Marubayashi S, Yahata H, Asahara T, Fujii S, Arihiro K, Dohi K: Granular cell tumor of the breast: report of a case. Hiroshima J Med Sci. 1999, 48 (1): 31-3.PubMedGoogle Scholar
- Kuhl CK, Klaschik S, Mielcarek P, Gieseke J, Wardelmann E, Schild HH: Do T2-weighted pulse sequences help with the differential diagnosis of enhancing lesions in dynamic breast MRI?. J Magn Reson Imaging. 1999, 9 (2): 187-96. 10.1002/(SICI)1522-2586(199902)9:2<187::AID-JMRI6>3.0.CO;2-2.View ArticlePubMedGoogle Scholar
- Scaranelo AM, Bukhanov K, Crystal P, Mulligan AM, O'Malley FP: Granular cell tumour of the breast: MRI findings and review of the literature. Br J Radiol. 2007, 80 (960): 970-4. 10.1259/bjr/95130566.View ArticlePubMedGoogle Scholar
- Uzoary I, Filter B: "Malignant GCT". Arch Pathol Lab Med. 1992, 116: 206.Google Scholar