Anatomical variation of co-existence of 4th and 5thshort metacarpal bones, sesamoid ossicles and exostoses of ulna and radius in the same hand: a case report
© Tzaveas et al; licensee BioMed Central Ltd. 2008
Received: 07 July 2008
Accepted: 29 October 2008
Published: 29 October 2008
The anatomical variations of bones in the hand are common. The existence of exostosis and shortening of metacarpal bones has been described in the literature as part of the hereditary multiple exostosis syndrome but no case has been reported with the co-existence of sesamoid ossicles in the same patient.
We report a case with co-existence of distal ulnar and radial exostoses, 4th and 5th short metacarpals and sesamoid ossicles in the wrist area.
This variation may help the interpretation of pain or sensory disorders in the hand and wrist areas.
The anatomical variations of bones in the hand are usually related to the presence of pain caused by pressure over the tendons or the joint capsules. Occasionally sensory disorders involving the median nerve or the ulnar nerve may be present. Usually these kind of symptoms are caused by post-traumatic bone deformities but sometimes the existence of sesamoid ossicles or exostoses may be the cause of symptoms. The frequency of sesamoid ossicles in human hand is around 0.4% – 1.6%, according to O'Rahilly's research . The existence of short metacarpal bone is usually found in pseudohypoparathyroidism, in Turner syndrome and in cases with familial short stature [2–4]. The exostoses is present in patients with osteochondromatosis or multiple hereditary exostoses, which is an autosomal dominant disorder consisting of multiple cartilaginous – capped exostoses (osteochondromas) arising from the metaphyses of bones and formed by cartilage . We present the co-existence of short metacarpal bones, exostoses and sesamoid ossicles in the same patient's hand, which is a rare anatomical variation. Such anatomical variations can be important for the interpretation of pain and sensory loss in some patients without history of fracture, other trauma or surgical intervention in the hand and wrist area.
The exostoses or osteochondromas are the most frequent benign bone tumors. They constitute 20% – 50% of all benign bone tumors and 10% – 15% of all bone tumors [6, 7]. They are cartilage – capped excrescences of bone that develop during physeal growth . Usually they do not cause any symptoms and they constitute incidental findings. Sometimes they may cause pain or sensory disorders because of fracture, pressure upon tendons, joint capsules, nerves or vessels. These complications seem to occur more often in an autosomal dominant syndrome called "hereditary multiple exostosis" . This syndrome appears with multiple exostoses in the metaphysis of long bones and affects individuals from early childhood until puberty. Individuals with hereditary multiple exostosis are often short in stature with varying degrees of orthopaedic deformity . Malignant transformation is seen in 1% of solitary osteochondromas and in 3% – 5% of patients with hereditary multiple exostoses . When malignant transformation or other complications appear, surgery may be required .
The incidence of the sesamoid bones in human hand is around 0.4 – 1.6% . The sesamoids may be involved in fractures, luxation, subluxation, osteoarthritis, osteochondritis, tendon ruptures and pressure phenomena . The sesamoid ossicle that lies under the triquetral bone is called "os hypotriquetrum" and its incidence is around 0.5% . The second sesamoid bone of our case is called "os Vasalius", after the name of Vasalius, who was the first to describe a sesamoid ossicle in 1593. This particular sesamoid was primarily described by Dwight in 1907 and its frequency is around 0.3% .
The short metacarpals are part of many syndromes. The presence of short 4th metacarpal is known as the "4th metacarpal bone sign" in patients with pseudohypoparathyroidism. A short 5th metacarpal may also be present in this condition . Other conditions associated with short 4th or 5th metacarpals include Turner syndrome, hereditary multiple exostosis , and other less common syndromes . They also appear in patients with homocystinuria . Shortening of 4th and 5th metacarpal do not seem to be pathognomic findings in the above syndromes.
Awareness of the anatomical variations of the hand may be important for the interpretation of pain and sensory deficits in this area. The presence of exostosis is something common as this kind of benign tumor is the most frequent, but they may also be part of hereditary multiple exostosis syndrome. The incidence of sesamoids in hand and wrist area is 0.4% to 1.6%  and they may involve many pathological conditions . Shortening of the 4th and 5th metacarpals is also a condition that may emerge the suspicion of some syndromes like pseudohypoparathyroidism, Turner syndrome, hereditary multiple exostosis and others . The co-existence of these conditions must be considered as something very rare in the literature.
An informed written consent has been received for publication of the present case report from the patient.
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