Skip to main content

Table II Immunohistochemical Data of Reported Cases per Years represented by percentage of positive cases

From: Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Immunohistochemistry

2008 - 200022 cases

1999 - 199030 cases

1989 - 196723 cases

Total of positive test(2008-1967)

Chromogranin A

86 %

53 %

25 %

44 %

Neuron Specific Enolase (NSE)

59 %

51 %

29 %

39 %

MET secretory granule

4.5 %

33 %

58 %

26 %

Synaptophysin

50 %

24 %

-

20 %

Serotonin

5 %

40 %

25 %

20 %

Vimentin

14 %

27 %

21 %

17 %

Cytokeratin

14 %

30 %

12 %

16 %

Keratin

14 %

20 %

21 %

15 %

Pancreatic polypeptide (PP)

-

30 %

21 %

15 %

Grimelius

5 %

20 %

17 %

12 %

Glucagon

-

17 %

17 %

10 %

Epithelial Membrane Antigen (EMA)

18 %

-

17 %

8 %

Protein S-100

-

10 %

12 %

6 %

  1. Immunohistochemistry positive result less than 5% (are not reported in the table) of cases for the period from 1967 to 2008: Cytokeratin AE1 / AE3, Cytokeratin cocktails, Cytokeratin KL 1, Cytokeratin CAM, Carcino Embryogenic Antigen (CEA), Periodic Acid-Schiff (PAS), Tissue polypeptide antigen (TPA), Calcitonin, Lyzozyme, Leu-7, Cholecystokinin, Fontana-Masson, Protein gene product 9.5 (PGP), Stomatostatine, Vasoactive intestinal polypeptide (VIP).