Skip to main content

Archived Comments for: Non-healing painful ulcers in a patient with chronic kidney disease and role of sodium thiosulfate: a case report

Back to article

  1. What was the cause of death and impressed by the report of pain relief

    Melvin Hayden, University of Missouri School of Medicine Division of Endocrinology Diabetes and Metabolism

    2 December 2009

    Thank you for sharing you interesting case report with calciphylaxis.

    I thought the relief of pain was rather classical and seems to be a an exciting outcome for the pain is horrendous and actually horrific.

    What was the cause of death in your patient as this was not discussed in your case report. Also what was the time interval between the onset of the eschar you shared and death?

    How can we be certain that the sodium thiosulfate was not promoting wound healing if the patient died as it frequently takes 3-6 months for these lesions to heal. Do you have any images of the skin ulceration after 2 months as there could be evidence of healing at the wound margin.

    I look forward to your comments and response.

    If you prefer you may feel free to correspond with me by e-mail:

    Thank you again for sharing this most interesting case report and I wish to thank Cases Journal and their editors for allowing case reports such as this case to be reported and shared with the readers of Bio Med Central. M.R. "Pete" Hayden, MD.

    Regarding new thoughts and ideas in evolution. There is growing interest in the development of low levels of hepatic synthesized fetuin-A,which is surpressed concurrent with albumin when the innate immune system is activated due to redox stress and activation of NFkappaB by reactive oxygen species and subsequent downstream inflammatory cytokines. pete hayden

    Competing interests

    None declared