Skip to main content

Advertisement

Table 1 Immunohistochemical staining pattern in the present case

From: Carcinoma developing in ectopic pancreatic tissue in the stomach: a case report

Antibody Gastric tumor site Gastric heterotopic pancreas site Description & use of antibody
CEA (+) (++) Oncofetal antigen in gastrointestinal, breast, lung, pancreas and other cancers.
CA 19-9 (-) (-) Useful cerum marker in gastrointestinal and pancreatic cancer; strongest staining in pancreatic cancer.
Cytokeratin 7 (+) (++) Typically found in simple epithelia from the GI tract; lesser degree of expression in gastric cancer.
Cytokeratin 19 (+) (-) Cytokeratin filament in a large number of epithelial cell types, including many ductal and glandular epithelia.
Cytokeratin 20 (±) (-) Restricted expression in intestinal epithelium, gastric foveolar epithelium and others; lesser degree of expression in pancreatic cancer.
MUC1 (-) (+) Glycoprotein of glandular epithelial tissues; modifications to glycosylation of musins in cancer; "gastric mucin" & "PanINs mucin".
Ki-67 (++) (-) The assessment of cell proliferation in neoplastic cell populations
  1. CA, carbohydrate antigen; CEA, carcinoembryonic antigen; MUC, mucin (transmembrane glycoprotein tumor antigen); -, < 5% cells stained; +, 30–70% cells stained; ++, > 70% cells stained; ±, 5–30% cells stained; GI, gastrointestinal; PanIns, pancreatic intraepithelial neoplasias