Drug | Cyclea |
|---|
| Â | #1 | #2 | #3b | #4 | #5c |
Bortezomib | 1.3 mg/m2 | 1.3 mg/m2 | 1.0 mg/m2 | Not given | 0.7 mg/m2 |
Doxorubicin | 5 mg/m2 | 5 mg/m2 | 5 mg/m2 | 4 mg/m2 | 10 mg/m2 |
Dexamethasone (IV) | 40 mg | 40 mg | 40 mg | 40 mg | 40 mg (PO) |
- a Each cycle with the exception of cycle #5 consisted of four scheduled doses on days 1, 4, 8, and 11. All three drugs were administered on each day unless otherwise stated. A cycle was started every 28 days.
- b Bortezomib and doxorubicin were held on cycle 3, day 11 due to progressive peripheral neuropathy.
- c Cycle #5 consisted of one dose of bortezomib on day 1, two doses of doxorubicin on days 1, and 8 and four doses of oral dexamethasone on days 1, 2, 8, and 9.
