Table 1 Reported cases of neuropsychiatric manifestations due to Cryptococcus neoformans
Reference | Age, Gender | Location | Symptoms | Immune status | Definitive diagnostic test | Treatment/Outcome |
|---|---|---|---|---|---|---|
Present case | 28, Female | India | Insomnia, Irritability, Psychosis, impaired reality testing, confusion | Immune-competent | CSF Culture | Amphotericin B; Recovery after 12 weeks |
Ref. [3] | 25, Female | China | Elated mood, logorrhoea, flight of ideas, disorientation, | Not mentioned | CSF Culture, Cryptococcal antigen test | Amphotericin B; Recovery after 16 weeks |
Ref. [4] | 63, Male | USA | Insomnia, restless, irritable, agitation, social dis-inhibition | Not mentioned | CSF Culture, Cryptococcal antigen test | Amphotericin B; Recovered |
Ref. [5] | 32, Male | USA | Insomnia, auditory and visual hallucinations, paranoid delusions | Immune-compromised | CSF (India Ink) Blood culture | Recovered |
Ref. [5] | 35, Male | USA | Poor sleep, Intrusive, hyperactive | Immune-compromised | CSF (India Ink) | Died |
Ref. [6] | 38, Male | Papua New Guinea | Restlessness, elated mood, delusions | Immune-competent | Serum Cryptococcal antigen test | Died |
Ref. [7] | 27, Male | France | Hallucinations, Delusional ideas | Immune-compromised | CSF (India Ink) Culture | Recovered |
Ref. [8] | 22, Male | Kuwait | Confusion Psychosis | Not mentioned | CSF Culture | Amphotericin and 5-flurocytosine; Recovered |
Ref. [9] | 57, Male | Israel | Vascular dementia | Immune-competent | CSF (India Ink) Culture Serum and CSF Cryptococcal antigen test | Amphotericin B, 5-Flucytosine followed by Flucanazole; Recovered |