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Table 1 Reported cases of neuropsychiatric manifestations due to Cryptococcus neoformans

From: Neuropsychiatric manifestation of confusional psychosis due to Cryptococcus neoformans var. grubii in an apparently immunocompetent host: a case report

Reference Age, Gender Location Symptoms Immune status Definitive diagnostic test Treatment/Outcome
Present case 28, Female India Insomnia, Irritability, Psychosis, impaired reality testing, confusion Immune-competent CSF Culture Amphotericin B; Recovery after 12 weeks
Ref. [3] 25, Female China Elated mood, logorrhoea, flight of ideas, disorientation, Not mentioned CSF Culture, Cryptococcal antigen test Amphotericin B; Recovery after 16 weeks
Ref. [4] 63, Male USA Insomnia, restless, irritable, agitation, social dis-inhibition Not mentioned CSF Culture, Cryptococcal antigen test Amphotericin B; Recovered
Ref. [5] 32, Male USA Insomnia, auditory and visual hallucinations, paranoid delusions Immune-compromised CSF (India Ink)
Blood culture
Ref. [5] 35, Male USA Poor sleep, Intrusive, hyperactive Immune-compromised CSF (India Ink) Died
Ref. [6] 38, Male Papua New Guinea Restlessness, elated mood, delusions Immune-competent Serum Cryptococcal antigen test Died
Ref. [7] 27, Male France Hallucinations, Delusional ideas Immune-compromised CSF (India Ink) Culture Recovered
Ref. [8] 22, Male Kuwait Confusion Psychosis Not mentioned CSF Culture Amphotericin and 5-flurocytosine; Recovered
Ref. [9] 57, Male Israel Vascular dementia Immune-competent CSF (India Ink) Culture
Serum and CSF Cryptococcal antigen test
Amphotericin B, 5-Flucytosine followed by Flucanazole; Recovered