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Table 1 Systematic review of previously published case reports using bisphosphonate treatment in patients with vitamin D intoxication.

From: Dihydrotachysterol intoxication treated with pamidronate: a case report

Ref.

Age, Sex

Underlying disease

Vitamin D compound

Serum Ca/P (mg/dl)

Creatinine (mg/dl)

PTH (pg/ml)

25 OH D3 (ng/ml)

Treatment

Other treatment

Response time

4.

40 years, M

Hypoparathyroidism

Ergocalciferol 100.000 U/day for 3 years

13.0

4.2

 

121

Disodium etidronate 400 mg

Hydration, prednisone

42 weeks

5.

7 months

None

Vitamin D

    

Alendronate

  

6.

3 months, M

None

Vitamin D 1.200.000 U/day

18.5/3.2

 

< 1.0

360

Alendronate 5-10 mg/day

Hydration, diuretics

18 days

7.

31 years, F

Hypoparathyroidism

Dyhydrotahysterol 4 mg/day for 6 months

4.1 mmol

5.5

  

Pamidronate 20 mg once

Hydration, diuretics

20 weeks

8.

16 months, M

None

Vitamin D

18

   

Pamidronate

Hydration, furosemide, glucocortioids

 

9.

8 months, F

Vitamin D deficiency

25-hydroxy vitamin D 1.200.000 U

14.2/4.8

 

< 3

210

Alendronate 5 mg/day

Hydration, furosemide

3 days

9.

35 days, M

Vitamin D deficiency

25-hydroxy vitamin D 600.000 U

14.5/5.9

 

< 3

240

Alendronate 5-10 mg/day

Hydration, furosemide

8 days

10.

3 months, M

None

Vitamin D 2.560.000 U

16.4/6.7

  

268

Pamidronate 20 mg twice

Hydration, furosemide, prednisolone

36 hours

11.

6 months

None

Vitamin D

    

Pamidronate 1 mg/kg/day twice

Hydration, furosemide, calcitonine, prednisolone

2 days

12.

11 months, F

None

Cholecalciferol > 900.000 U

18

 

1.84

200

Alendronat 5 mg/day for 21 days

Calcitonine, glucocorticoid, oral phosphates

3 weeks

12.

4 months, F

Misdiagnosed for rickets

Cholecalciferol 600.000 U

14.9

 

4.1

> 160

Pamidronate, 1 mg/kg/day for 9 days, alendronate 10 mg/day for 6 weeks

Hydration, glucocrticoids, calcitonin, phosphates

9 weeks

13.

77 years, F

Osteoporosis

Vitamin D 50.000 U/day for 6 days

21

1.9

 

280

Pamidronate 90 mg once

Hydration

24 hours

14.

7 years, M

Vitamin D deficiency

Vitamin D 300.000 U/day for 15 days

12.1/3.4

  

> 400

Alendronate 5-10 mg

Hydration, diuretic

16 days

15.

76 years, F

Hypoparathyroidism

Ergocalciferol 100.000 U/day, 12 years

15.3/3.0

   

Pamidronate 45 mg five times

Hydration, prednisolone

11 months