Skip to main content

Table 1 Systematic review of previously published case reports using bisphosphonate treatment in patients with vitamin D intoxication.

From: Dihydrotachysterol intoxication treated with pamidronate: a case report

Ref. Age, Sex Underlying disease Vitamin D compound Serum Ca/P (mg/dl) Creatinine (mg/dl) PTH (pg/ml) 25 OH D3 (ng/ml) Treatment Other treatment Response time
4. 40 years, M Hypoparathyroidism Ergocalciferol 100.000 U/day for 3 years 13.0 4.2   121 Disodium etidronate 400 mg Hydration, prednisone 42 weeks
5. 7 months None Vitamin D      Alendronate   
6. 3 months, M None Vitamin D 1.200.000 U/day 18.5/3.2   < 1.0 360 Alendronate 5-10 mg/day Hydration, diuretics 18 days
7. 31 years, F Hypoparathyroidism Dyhydrotahysterol 4 mg/day for 6 months 4.1 mmol 5.5    Pamidronate 20 mg once Hydration, diuretics 20 weeks
8. 16 months, M None Vitamin D 18     Pamidronate Hydration, furosemide, glucocortioids  
9. 8 months, F Vitamin D deficiency 25-hydroxy vitamin D 1.200.000 U 14.2/4.8   < 3 210 Alendronate 5 mg/day Hydration, furosemide 3 days
9. 35 days, M Vitamin D deficiency 25-hydroxy vitamin D 600.000 U 14.5/5.9   < 3 240 Alendronate 5-10 mg/day Hydration, furosemide 8 days
10. 3 months, M None Vitamin D 2.560.000 U 16.4/6.7    268 Pamidronate 20 mg twice Hydration, furosemide, prednisolone 36 hours
11. 6 months None Vitamin D      Pamidronate 1 mg/kg/day twice Hydration, furosemide, calcitonine, prednisolone 2 days
12. 11 months, F None Cholecalciferol > 900.000 U 18   1.84 200 Alendronat 5 mg/day for 21 days Calcitonine, glucocorticoid, oral phosphates 3 weeks
12. 4 months, F Misdiagnosed for rickets Cholecalciferol 600.000 U 14.9   4.1 > 160 Pamidronate, 1 mg/kg/day for 9 days, alendronate 10 mg/day for 6 weeks Hydration, glucocrticoids, calcitonin, phosphates 9 weeks
13. 77 years, F Osteoporosis Vitamin D 50.000 U/day for 6 days 21 1.9   280 Pamidronate 90 mg once Hydration 24 hours
14. 7 years, M Vitamin D deficiency Vitamin D 300.000 U/day for 15 days 12.1/3.4    > 400 Alendronate 5-10 mg Hydration, diuretic 16 days
15. 76 years, F Hypoparathyroidism Ergocalciferol 100.000 U/day, 12 years 15.3/3.0     Pamidronate 45 mg five times Hydration, prednisolone 11 months