Table 1

Authors

Title

Journal

Cases

Age

Sex

Clinical presentation

Radiological presentation

Therapy

Outcome

Comments

Jeganathan et al. [6]

Primary mediastinal synovial sarcoma.

Ulster Med J 2007; 76:109-111

1

59

m

non-specific abdominal pain

large mass in left thoracic cavity, adjacent to the mediastinum

surgery

disease free 18 months post-operative

F-18 FDG PET scans were performed with increased uptake of the tumor

Gotoh et al. [7]

Synovial sarcoma of the mediastinum: report of a case.

Surg Today 2004; 34:521-524

1

50

m

anterior chest pain

10 × 8 cm mass in the right anterior mediastinal space, no sign of chest wall invasion or disseminated lesions

surgery, chemotherapy (ifosfamide)

patient is alive 9 month after operation

local recurrence in the right pleural cavitiy and metastasis to mediastinal lymph node were detected 9 months postoperatively

Witkin et al. [8]

A biphasic tumor of the mediastinum with features of synovial sarcoma. A report of four cases.

Am J Surg Pathol 1989; 13:490-499

4

range 40-73

m

localized symptoms: hoarseness and cough / dyspnea and palpitations / hemoptysis

solitary mediastinal masses

surgery and radiotherpay / surgery, chemotherapy and palliative radiotherapy / 2 had only surgery

3 patients died of their disease 14 months / 4 years / 10 months after diagnosis

-

Trupiano et al. [9]

Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis.

Ann Thorac Surg 2002; 73:628-630

2

67 / 30

m / f

first patient had chest pain and shortness of breath / second presented incidental

9.0 cm soft tissue mass extending over the cardiac apex / 17.0 cm anterior mediastinal mass

surgery (partial pericardectomy), radiation / partial resection (pericardectomy) and wedge resection of the left upper lobe of the lung, multiagent chemotherapy

alive after 18 months after diagnosis / expired 10 months after inital presentation

-

Hsieh et al. [10]

Synovial sarcoma of the mediastinum.

Zhonghua Yi Xue Za Zhi (Taipei) 2002; 65:83-85

1

11

m

facial edema, flushing, poor appetite and fatigue

widening superior mediastinum with increased densitiy, CT showed a big mass in the right superior mediastinum with chest wall invasion

surgery, chemotherapy, radiation

alive 2 years after diagnosis

-

Suster et al. [11]

Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases.

Am J Surg Pathol 2005; 29:569-578

15

range 3-83

male to female ratio 2:1

chest pain, shortness of breath, neck or back pain, 4 patients had also constitutional symptoms such as fever, weight loss and weakness

tumor located in posterior mediastinum (6) / anterior mediastinum (6) / anterior-middle mediastinum (3)

complete surgical excision (10), partial excision followed by radiation (2), only radiation (3)

follow-up was available for 5 patients, 4 had local recurrence (follow-up from 1-3 years) and one patient died of tumor 6 months after diagnosis with liver metastases

4 cases had biopsy-proven metastases to hilar lymph node, lung, liver and epidural space

Al-Rajhi et al. [12]

Primary pericardial synovial sarcoma: a case report and literature review.

J Surg Oncol. 1999 Mar; 70(3):194-198

1

19

m

shortness of breath

large heart in chest X-ray, echocardiogramm indicated a pericardial mass and effusion, MRI revealed a 7 × 6 × 7.5 cm enhancing mass arising from pericardium

surgery with partial pericardectomy and radiation

free of disease 12 months after operation

first known pericardial synovial sarcoma

Kaira et al. [13]

Primary mediastinal synovial sarcoma: a report of 2 cases.

J Comput Assist Tomogr. 2008 Mar-Apr; 32(2):238-241.

2

64 / 58

f / m

right back pain and dysphagia / right back pain

heterogenous enhancing mass in the left posterior mediastinal space / posterior mediastinal mass

radiation and chemotherapy (ifosfamide and adriamycin) / radiation and chemotherapy (ifosfamide and adriamycin; gemcitabine and docetaxel; carboplatin and paclitaxel)

died 24 and 19 months after the initial diagnosis, respectively

in both cases no surgery, the neoplasm was unresectable