- Case Report
- Open Access
Severe vitamin D deficiency presenting as hypocalcaemic seizures in a black infant at 45.5 degrees south: a case report
Cases Journal volume 1, Article number: 12 (2008)
A 5 month old black infant presented to the Emergency Department in the spring with generalised seizures. He was found to have severe vitamin D deficiency and hypocalcaemia. The baby had been born healthy in the autumn at 45.5 degrees south to parents of African extraction, had been fully breast-fed since birth and had spent some time in day care over the winter months. His mother was a professional working woman who had not taken any vitamin or nutritional supplements during pregnancy or lactation.
Vitamin D deficiency and rickets used to be commonplace however with the discovery that vitamin D was synthesised following sun exposure, and with vitamin D fortification of some common foods, were thought to have been eradicated. Unfortunately, however, vitamin D deficiency and rickets are again becoming a major global health issue .
While vitamin D deficiency in children usually presents as rickets, when severe such deficiency may result in hypocalcaemic seizures. Vitamin D deficiency prevents the efficient absorption of dietary calcium and phosphorus leading to an increased secretion of parathyroid hormone which conserves serum calcium by mobilising calcium stores from the skeleton. Serum calcium levels are thus usually preserved in vitamin D deficient children, however when the calcium stores in the skeleton are totally depleted the infant will become hypocalcaemic .
A 5 month old black infant presented to the Emergency Department in the springtime with generalized seizures. The baby had received his routine 5 month immunisations several hours earlier that day, which he tolerated well, and had no history of health or developmental concerns. The baby had been born healthy at term in the autumn at latitude 45.5 degrees south and had been exclusively breast fed since birth. His parents were professionals of African origin and the baby had spent some time in day care over the winter months. The baby's mother was a fit and well 39 year old lawyer with two older children. She had not taken any nutritional or vitamin supplements during pregnancy or lactation.
On admission the baby was found to have severe vitamin D deficiency, hypocalcaemia and iron deficiency. There were no clinical signs of rickets however wrist X rays revealed evidence of rickets. Urine tests revealed a urinary infection.
Tests results on admission: (see table 1)
The baby made a full recovery after treatment with calcium, magnesium, vitamin D, iron, and antibiotics.
Most people, including babies, get most of their vitamin D through exposure to sunlight (UVB)  The duration of sun exposure required to produce a given amount of vitamin D depends upon the amount of skin exposed, skin melanin content, use of sun block, glass cover, cloud cover, latitude, season  and age. Melanin, sun-block, and glass absorb UVB, diminishing the production of vitamin D from sun exposure by more than 90% . At higher latitudes (above 30 degrees), because of the increased path length for the sun's UVB rays, most UVB is absorbed in the stratospheric ozone meaning that very little vitamin D can be produced in the skin over the winter months .
During times of reduced exposure to sunlight, vitamin D status is related to dietary vitamin D intake. It is, however, difficult to achieve adequate vitamin D intake through dietary measures alone and consequently serum vitamin D levels tend to be lower at the end of winter  and may become dangerously low in at risk individuals. Breast milk contains very little, if any, vitamin D [4, 5] Those most at risk of vitamin D deficiency include pregnant women, breast fed infants and the elderly, in particular those living at high latitudes who have dark skin, wear burka or follow strict sun avoidance practices.
Vitamin D deficiency can cause serious health problems. In addition to rickets and hypocalcaemic seizures, vitamin D deficiency has been implicated in a number of health problems including immune dysfunction, increased risk of type I diabetes , increased risk of cancers of the colon, prostate, breast, ovary, oesophagus, and several other tissues , as well as falls, poor dental health and cardiovascular disease .
To prevent vitamin D deficiency, many northern hemisphere countries have routine vitamin D fortification of foods  however in New Zealand we have limited vitamin D fortification, making routine screening and treatment of pregnant women, and routine supplementation of breast fed infants of dark skinned or veiled women, important considerations .
Written informed consent was obtained from the patient's parents for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Holick MF: Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006, 116 (8): 2062-2072. 10.1172/JCI29449.
Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J, Charles P, Eriksen EF: Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000, 247 (2): 260-268. 10.1046/j.1365-2796.2000.00595.x.
Livesey J, Elder P, Ellis MJ, McKenzie R, Liley B, Florkowski C: Seasonal variation in vitamin D levels in the Canterbury, New Zealand population in relation to available UV radiation. N Z Med J. 2007, 120 (1262): U2733.
Hollis BW, Wagner CL: Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr. 2004, 79 (5): 717-726.
Dawodu A, Wagner CL: Mother-child vitamin D deficiency: an international perspective. Arch Dis Child. 2007, 92 (9): 737-740. 10.1136/adc.2007.122689.
Zipitis CS, Akobeng AK: Vitamin D Supplementation in Early Childhood and Risk of Type 1 Diabetes: a Systematic Review and Meta-analysis. Arch Dis Child. 2008
Holick MF: High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006, 81 (3): 353-373.
Holick MF: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004, 79 (3): 362-371.
Rockell JE, Green TJ, Skeaff CM, Whiting SJ, Taylor RW, Williams SM, Parnell WR, Scragg R, Wilson N, Schaaf D, Fitzgerald ED, Wohlers MW: Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 y. J Nutr. 2005, 135 (11): 2602-2608.
Munns C, Zacharin MR, Rodda CP, Batch JA, Morley R, Cranswick NE, Craig ME, Cutfield WS, Hofman PL, Taylor BJ, Grover SR, Pasco JA, Burgner D, Cowell CT: Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: a consensus statement. Med J Aust. 2006, 185 (5): 268-272.
The author expresses her gratitude to the baby's parents for their consent to publish this information.
The author declares that they have no competing interests.
About this article
Cite this article
Wallis, K. Severe vitamin D deficiency presenting as hypocalcaemic seizures in a black infant at 45.5 degrees south: a case report. Cases Journal 1, 12 (2008). https://doi.org/10.1186/1757-1626-1-12
- Calcium Store
- Melanin Content
- Severe Vitamin
- Black Infant