Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: A case report
© Mori et al; licensee BioMed Central Ltd. 2008
Received: 05 September 2008
Accepted: 19 September 2008
Published: 19 September 2008
A 54-year-old man was admitted to the hospital presenting with a 3-month history of sclerosing dermal lesion in the external genitalia. A scrotal skin biopsy revealed a poorly-differentiated adenocarcinoma, immunohistochemically positive for cytokeratin 7 (CK7) and for thyroid transcription factor 1 (TTF-1), and negative for CK20. One month after admission, he died of respiratory failure. At autopsy, a consolidating lesion with vague margin was noted in the left lung as well as a well-circumscribed nodule in the right lobe of the thyroid. Histopathologically, pulmonary lesion was adenocarcinoma with a micropapillary component. On the other hand, thyroid tumor was diagnosed as a follicular variant of papillary carcinoma with foci of micropapillary adenocarcinoma. Positive immunohistochemistry for surfactant protein on micoropapillary component was useful to confirm that micropapillary component was of lung adenocarcinoma origin.
Carcinomas with micropapillary components have been reported as rare but poorly prognostic tumors in various organs including the breast, urinary bladder, lung, ovary, and major salivary glands [1–4]. Not only the characteristic morphologic pattern but also aggressive manifestations including severe lymph node metastases and lymphovascular infiltration make the tumors as distinctive entity of adenocarcinoma. In this report we describe a case of lung adenocarcinoma with micropapillary component presenting as metastatic skin lesion and cancer-to-cancer metastasis to thyroid papillary carcinoma.
Immunohistochemical analysis of tissue samples taken at autopsy confirmed that tumor cells in the lung MPCs, thyroid papillary carcinoma, and thyroid MPC-like clusters were all positive for CK7 but negative for CK20. TTF-1 staining demonstrated weakly positive in lung MPC and in thyroid papillary carcinoma follicular variant, whereas thyroid MPC-like clusters were negative. Furthermore, thyroglobulin was positive in thyroid papillary carcinoma with follicular variant, while negative in the MPC-like clusters in both thyroid and lung. On the other hand, lung adenocarcinoma and metastatic MPCs, including MPC in thyroid tumor (Fig. 2C), were exclusively positive for surfactant protein. These findings suggested that MPC-like clusters in the thyroid papillary carcinoma was metastatic tumor derived from lung cancer. Immunohistochemical analysis for D2-40 confirmed that the MPC was not located within a lymph vessel but in clear tissue space.
Carcinomas with MPC were rare but aggressive tumors with poor prognosis. According to the review article, these tumors have predilections for mammary gland, urinary bladder, lung and salivary gland . Also colon-derived cases are reported recently . Histopathologically, cancer with MPC is characterized by clusters of tumor cells with no fibrovascular cores surrounded by clear spaces resembling dilated lymphatic channels, and inner surface of the cavity demonstrates negative immunoreactivity for endothelial (e.g. factor VIII-related antigen and CD31) nor lymphatic endothelial markers (e.g. D2-40). Additionally each cluster has inversed basal-apical polarity of glandular structure [5, 6], suggesting that stroma-facing (basal) surface of the cells acquires apical secretory properties and secrets molecules responsible for stromal/vascular invasion such as metalloproteinases, making this type of tumors aggressive .
In this case, because immunohistochemical analysis for TTF-1 and CK7/CK20 suggested that primary focus can either be thyroid cancer or lung adenocarcinoma, we used surfactant protein as a selective marker for the lung cancer. With positive immunohistochemistry for the surfactant protein and systemic analysis by autopsy, we concluded that this case is a primary lung adenocarcinoma with MPC with cancer-to-cancer metastasis. Lack of obvious head and neck lymph node metastasis (e.g. deep cervical nodes) in spite of massive lymph nodes metastases seen in thoracoabdominal cavity also supported that MPC is derived from the lung.
In summary, we reported an autopsy case of lung cancer with MPC metastasizing to the thyroid papillary carcinoma. Wide spreading systemic metastasis clearly illustrates the aggressive character of cancers with this particular histopathological feature.
Written informed consent was obtained from the patient' family for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors thanks Shuichi Matsuda, Noriko Sakamoto, Miki Zenigami for their excellent technical assistance.
- Nassar H: Cacinoma with micropapillary morphology: Clinical significance and current moncepts. Adv Anat Pathol. 2004, 11: 297-303. 10.1097/01.pap.0000138142.26882.fe.View ArticlePubMedGoogle Scholar
- Nagao T, Gaffey TA, Visscher DW, Kay PA, Minato H, Serizawa H, Lewis JE: Invasive micropapillary salivary duct carcinoma: A distinct histologic variant with biologic significance. Am J Surg Pathol. 2004, 28: 319-326. 10.1097/00000478-200403000-00004.View ArticlePubMedGoogle Scholar
- Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, Nakata H, Taniguchi H, Enzan H: Pulmonary adenocarcinoma with micropapillary component: An immunohistochemical study. APMIS. 2005, 113: 550-554. 10.1111/j.1600-0463.2005.apm_151.x.View ArticlePubMedGoogle Scholar
- Amin MB, Tamboli P, Merchant SH, Ordóñez NG, Ro J, Ayala AG, Ro JY: Micropapillary component in lung adenocarcinoma: A distinctive histologic feature with possible prognostic significance. Am J Surg Pathol. 2002, 26: 358-364. 10.1097/00000478-200203000-00010.View ArticlePubMedGoogle Scholar
- Luna-More S, Gonzales B, Acedo C, Rodrigo I, Luna C: Invasive micropapillary carcinoma of the breast. A new special type of invasive mammary carcinoma. Pathol Res Pract. 1994, 190: 668-674.View ArticlePubMedGoogle Scholar
- Bejarano PA, Nikiforov YE, Swenson ES, Biddinger PW: Tyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms. Appl Immunohistochem Mol Morphol. 2000, 8: 189-194. 10.1097/00022744-200009000-00004.PubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.