Successful management of Influenza A associated fulminant myocarditis: mobile circulatory support in intensive care unit: a case report
© Montcriol et al; licensee BioMed Central Ltd. 2008
Received: 24 June 2008
Accepted: 18 July 2008
Published: 18 July 2008
A 26-year-old woman was referred to an Emergency Department because of common flu-like syndrome with hemodynamic collapse. In Intensive Care Unit (ICU), she was diagnosed as a probable septic shock. But despite treatment her condition rapidly deteriorated during the subsequent hours. Diagnosis of cardiogenic shock was established. Mechanical circulatory support was inserted into the patient. She was transferred in a Cardio-Vascular Surgical ICU where at the 5th day of mechanical circulatory support, echocardiography showed heart recovery which allowed weaning of mechanical circulatory support and progressive withdrawal of inotropic support. She was discharged at the 26th day. During her hospitalization, presence of Influenza A RNA was shown in myocardial biopsy.
Fulminant myocarditis causing severe hemodynamic dysfunction and requiring high-dose vasopressors or mechanical circulatory support is rare; however, intensive care unit physicians should be aware that its treatment may require the use of mobile circulatory support devices. We report a case of acute fulminant myocarditis caused by influenza A infection, a rare etiology, successfully treated by percutaneous extracorporeal membrane oxygenation (ECMO) with cardio-pulmonary bypass.
A previously healthy 26-year-old woman was referred to the Emergency Department with an influenza-like illness, which had started 2 days previously, and was associated with progressive disturbance of consciousness. Clinical examination was normal except for a blood pressure of 70/30 mmHg and a tachycardia of 120 beats/min. There was no response to a fluid challenge (1 L of colloid over 30 min). Central nervous system infection was ruled out by lumbar puncture and cerebral tomodensitometry. Her white blood cell count was 7,000 per μl and the procalcitonin concentration was not raised. EKG and chest radiography were normal. The first troponin measurement was 0.02 ng/mL.
The patient was transferred in a medical Intensive Care Unit (ICU) under the diagnosis of probable septic shock. Fluid resuscitation (4 L of cristalloids during the 6 first hours) was followed by a daily continuous infusion of 3 L of cristalloids and norepinephrine infusion. Antibiotics were given: cefotaxime (4 × 2 g/day, erythromycin 3 × 1 g/day and gentamycin 1 × 400 mg/day), plus intravenous hydrocortisone (200 mg per day).
Evolution of hemodynamic data, inotropic support and biology at the admission and during hospitalization in medical ICU
Before transfer in
Cardiac index (L × min-1 × m-2)
Urinary output (mL/h)
Dobutamine (μg × kg-1 × min-1)
Troponin I (ng/mL)
Lactate level (mmol/L)
ASAT (IU/L)/ALAT (IU/L)
Total bilirubin (mg/dL)
Factor V (%)
A circulatory support device was connected by percutaneous femoral vein and artery cannulation. Pump flow of 3500 rpm generated an output of 4 L/min and a non pulsatile systemic pressure of 80 mmHg. Intravenous heparin was given, aiming at an activated cephalin time of 60–80 secs. This procedure allowed rapid weaning of the inotropic support, and led to urine production and decreased lactacidemia (Table 1).
The patient was transferred to a Cardiac ICU 24 hours later. Echocardiography showed lower left and right heart pressures, but the LVEF was persistently low at 20%. Multiple biopsies of the myocardium were performed. These latter, using routine staining, revealed interstitial inflammation and tissue destruction, but bacterial cultures remained negative. Real time polymerase chain reaction showed the presence of Influenza A RNA in the biopsy. Influenza A infection was confirmed by serologic tests and positive culture of the endotracheal aspirate. Liver function tests improved during circulatory support but there was anuric renal failure. On the 5th day of mechanical circulatory support, echocardiography showed improved diastolic and systolic function (LVEF of 50%) which allowed the progressive withdrawal of inotropic support. Mechanical circulatory support was reduced on the 6th day, and was withdrawn 24 hours later. The empiric antibiotherapy was stopped on the 7th day; she was extubated on the 13th, and vasopressor support was withdrawn on the 15th. Renal function recovered after 20 days of continuous veno-venous hemofiltration. She was discharged on the 26th day with an LVEF of 70%, good diastolic function and no ventricular dilatation.
Myocarditis is an inflammation of the myocardium caused by viral, bacterial or protozoal infections, drug toxicity or immunological reactions. Viral myocarditis remains the prototype for the study of this disease and its evolution. Nevertheless few cases of Influenza-associated myocarditis have been reported [1–6].
The diagnosis of myocarditis may be difficult to make in the early stages of the disease. In this case, it was initially misdiagnosed as septic shock, in which myocardial dysfunction and mild troponin increase are commonly seen. This case report underlines the role of echocardiography for diagnosis and management of myocarditis . Left ventricular dysfunction is the most common abnormality reported during myocarditis but is unspecific. An increase in brightness, heterogeneity and contrast of the myocardium may suggest myocarditis. Furthermore, fulminant myocarditis could be distinguished from acute myocarditis by echocardiographic criteria. Patients with fulminant myocarditis typically have near-normal left ventricle diastolic dimensions with increased septal thickness at presentation, whereas those with acute myocarditis have increased diastolic dimensions but normal septal thickness . However, in this case report, septal thickness was normal. Endomyocardial biopsy is still considered by many to be the gold standard for diagnosing myocarditis. Drawbacks are that the results are delayed, and even if diagnosis is confirmed or an etiologic agent identified, no specific treatment recommendations for myocarditis can be made. Indeed, influenza antiviral agents like amantadine, rimadantine or neuraminidase inhibitors have not been tested in influenza-associated myocarditis and immune modulatory therapies have not proved themselves in controlled trials .
The treatment thus remains supportive. Intensive care physicians suspecting fulminant myocarditis must be prepared to use therapeutic options such as circulatory support before severe organ failure develops. Usually heart transplantation is delayed for weeks. This strategy is strongly supported by the fact that fulminant myocarditis are commonly reversible within a few days and have a better long-term prognosis than acute myocarditis .
Circulatory support is used to maintain cardiac output and organ perfusion, and to minimize the need for inotropic support until myocardial recovery. Alternatively it can be a bridge to long-term assist devices or heart transplantation. We choose a non-pulsatile, servo-regulated flow system driven by a centrifugal pump with a membrane oxygenator. It is relatively inexpensive, and can be set up within 30 min by percutaneous cannulation of the femoral vessels at the bedside, and can take over the function of both heart and lungs. Non-pulsatile blood flow is adequate for short term circulatory support (2–3 weeks) . Organ dysfunction can be prevented by setting a flow rate sufficient to normalize indicators of circulatory failure such as pH, lactate, and SVO2 . Left ventricular preload must be optimized and third space fluid reduced by normalizing oncotic pressure, avoiding excessive volume loading and using hemofiltration. It is essential to maintain sinus rhythm and to preserve left ventricular contractility with inotropic support, to prevent secondary myocardial damage and thrombotic complication induced by blood stagnation, even if systemic perfusion is maintained. Protective mechanical ventilation is maintained to oxygenate any blood delivered to the pulmonary vascular bed by residual myocardial activity, and to avoid atelectasis .
Complications associated with these devices are frequent. Then, even if these devices can be set up in an emergency unit, their routine management remains the role of specialized units. Furthermore, the decision to switch to a pulsatile paracorporeal or implantable systems allowing extended periods of support, or to proceed with heart transplantation before complications of long term extracorporeal circulatory support occur, remains one for experienced clinicians.
The diagnosis of fulminant myocarditis may be difficult in the intensive care unit and identification of the viral agent is uncommon. Echocardiography is invaluable when the hemodynamic status worsens despite normally adequate treatment. A human outbreak of avian Influenza A H5N1 could see many cases of influenza-associated myocarditis and thus intensive care unit physicians should be aware of the possibilities of mobile closed chest cardiopulmonary bypass.
Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
We gratefully acknowledge Pr L. Papazian and Dr C. Guidon for their helpful collaboration.
- Agnino A, Schena S, Ferlan G, De Luca T, Schinosa L: Left ventricular pseudoaneurysm after acute influenza A myocardiopericarditis. J Cardiovasc Surg (Torino). 2002, 43: 203-5.Google Scholar
- Engblom E, Ekfors TO, Meurman OH, Toivanen A, Nikoskelainen J: Fatal influenza A myocarditis with isolation of virus from the myocardium. Acta Med Scand. 1983, 213: 75-8.View ArticlePubMedGoogle Scholar
- Letouze N, Jokic M, Maragnes P, Rouleau V, Flais F, Vabret A, Freymuth F: [Fulminant influenza type A associated myocarditis: a fatal case in an 8 year old child]. Arch Mal Coeur Vaiss. 2006, 99: 514-6.PubMedGoogle Scholar
- Nolte KB, Alakija P, Oty G, Shaw MW, Subbarao K, Guarner J, Shieh WJ, Dawson JE, Morken T, Cox NJ, Zaki SR: Influenza A virus infection complicated by fatal myocarditis. Am J Forensic Med Pathol. 2000, 21: 375-9. 10.1097/00000433-200012000-00016.View ArticlePubMedGoogle Scholar
- Tabbutt S, Leonard M, Godinez RI, Sebert M, Cullen J, Spray TL, Friedman D: Severe influenza B myocarditis and myositis. Pediatr Crit Care Med. 2004, 5: 403-6. 10.1097/01.PCC.0000123555.10869.09.View ArticlePubMedGoogle Scholar
- McGovern PC, Chambers S, Blumberg EA, Acker MA, Tiwari S, Taubenberger JK, Carboni A, Twomey C, Loh E: Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditis. J Heart Lung Transplant. 2002, 21: 290-3. 10.1016/S1053-2498(01)00336-9.View ArticlePubMedGoogle Scholar
- Felker GM, Boehmer JP, Hruban RH, Hutchins GM, Kasper EK, Baughman KL, Hare JM: Echocardiographic findings in fulminant and acute myocarditis. J Am Coll Cardiol. 2000, 36: 227-32. 10.1016/S0735-1097(00)00690-2.View ArticlePubMedGoogle Scholar
- Magnani JW, Dec GW: Myocarditis: current trends in diagnosis and treatment. Circulation. 2006, 113: 876-90. 10.1161/CIRCULATIONAHA.105.584532.View ArticlePubMedGoogle Scholar
- Aoyama N, Izumi T, Hiramori K, Isobe M, Kawana M, Hiroe M, Hishida H, Kitaura Y, Imaizumi T: National survey of fulminant myocarditis in Japan: therapeutic guidelines and long-term prognosis of using percutaneous cardiopulmonary support for fulminant myocarditis (special report from a scientific committee). Circ J. 2002, 66: 133-44. 10.1253/circj.66.133.View ArticlePubMedGoogle Scholar
- Kerbaul F, Collart F, Bonnet M, Villacorta J, Guidon C, Gouin F: [Perioperative management of ventricular assist devices]. Ann Fr Anesth Reanim. 2003, 22: 609-28. 10.1016/S0750-7658(03)00141-2.View ArticlePubMedGoogle Scholar
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