A case of muscular bridge resulting in myocardial infraction following heavy effort: a case report
© Kurt; licensee BioMed Central Ltd. 2009
Received: 20 September 2008
Accepted: 10 February 2009
Published: 10 February 2009
Muscular bridge (MB) is transient systolic coronary blockage occurring due to exposure of a portion of epicardial coronary arteries to compression during systole as a result of tunneling into the myocardium. Although rare, these patients may develop angina pectoris, severe arrhythmia and myocardial infraction (MI). A 30-year-old male patient presented to the emergency with severe pain with an onset at the front part of the chest followed by spreading to the back and arms, during a football match. The investigations performed revealed anterior wall infraction and thus thrombolytic treatment was administered. Patient's history was normal except for smoking. The patient was detected to play football occasionally since his childhood; however, we learnt that he had started playing without warm-up exercises at the last football match. Coronary angiography detected a lesion with an onset in the left anterior descending artery following the 1st diagonal and extending to the 2nd diagonal and exhibiting a significant contraction during systole. The patient was considered to have myocardial infraction secondary to myocardial bridge. Sudden deaths frequently occur in competitive sports requiring heavy effort.
Myocardial bridge is the most common congenital abnormality of coronary artery disease. It is mainly localized in the proximal part of the left anterior descending artery. Although it leads to angina pectoris, it is usually of benign nature; however, it has been associated with severe ventricular arrhythmias and myocardial infraction . They have a silent clinical course since they are mostly asymptomatic. Post-mortem investigations and IVUS studies reveal a MB rate up to 80% ; however it is mostly demonstrated on the investigations performed upon onset of symptoms. In this report, a 30 year old male patient was presented, who experienced anterior MI secondary to MB following severe chest pain with an onset during a compelling football match played without a warm-up exercise period. Although myocardial bridges are asymptomatic, they may still cause sudden death and myocardial infraction during heavy effort.
Muscular bridge is transient systolic coronary blockage occurring due to exposure of a portion of epicardial coronary arteries to compression during systole as a result of tunneling into the myocardium. Myocardial bridge is reported at a rate of 0.5–12% on angiographic series [3, 4]. Most of the patients are young males . It is mostly located in the middle LAD and has a length ranging between 1 to 5 cm . Mostly, it is clinically asymptomatic and most of the exercise tests reveal no finding . In cases with myocardial bridge, myocardial infraction is presented in the form of case reports; in most of these cases, the pain occurs during exercise [8, 9]. Excessive physical and mental tension is suggested to increase the duration of vasospasm as a result of systolic compression, thereby leading to MI . In addition, systolic compression is suggested to lead to predisposition to thrombus by resulting in endothelium injury .
Tachycardia is suggested to induce MI in cases with MB . The IVUS studies usually reveal atherosclerotic plaque in the proximal segment of MB . These plaques are suggested to cause MI by cracking due to mechanic overload [3, 9]. Although rare, cases of MI secondary to MB following heavy exercise were reported . Formation of thrombus in the coronary artery was observed in cases of MI secondary to MB following excessive compelling . In our case, although LAD had a MB in a long segment, there was injury in a very small segment of the myocardium; this possibly resulted from the contribution of ischemic preconditioning as well as administration of thrombolytic treatment . Although the rate of MB cases is high, treatment is administered based on symptoms. Exercise test, myocardial perfusion scintigraphy, magnetic resonance and coronary flow reserve Doppler techniques are used to detect ischemia. However, in cases with MB, perfusion scintigraphy performed with vasodilating agents such as dipyridamole is reported to yield false results due to steal syndrome . For MB cases with findings of ischemia, there are therapeutical choices of coronary stent, coronary bypass and myotomy as well as medical treatment. Despite therapeutical choices, percutaneous and surgical treatment does not achieve much success. Therefore, beta-blockers and Ca++ antagonists are usually preferred as medical treatment. In such cases, use of beta-blockers is recommended, particularly in case of heavy exercise. In such cases, acetyl salicylic acid may be added to treatment for prophylactic purposes. The myocardial (MIBI) perfusion scintigraphy performed after 3 months while the patient was on beta-blocker revealed no ischemic findings.
Although the incidence of MB is very high in the society, it is not considered very important since MB does not cause serious complaints. Although rare, mortal outcomes such as MI and sudden death may be observed in some cases. Sudden deaths frequently occur in competitive sports requiring heavy effort.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Vasan RS, Bahl VK, Rajani M: Myocardial infarction associated with a myocardial bridge. Int J Cardiol. 1989, 25: 240-1. 10.1016/0167-5273(89)90115-0.View ArticlePubMedGoogle Scholar
- Ge J, Jeremias A, Rupp A, Abels M, Baumgart D, Liu F, et al: New signs characteristic of myocardial bridging demonstrated by intracoronary ultrasound and Doppler. Eur Heart J. 1999, 20: 1707-16. 10.1053/euhj.1999.1661.View ArticlePubMedGoogle Scholar
- Rossi L, Dander B, Nidasio GP, Arbustini E, Paris B, Vassanelli C, et al: Myocardial bridge sand ischemic heart disease. Eur Heart J. 1980, 1: 239-245.PubMedGoogle Scholar
- Soran O, Pamir G, Erol C, Kocakavak C, Sabah I: The incidence and significance of myocardial bridge in a prospectively d defined population of patients undergoing coronary angiography for chest pain. Tokai J Exp Clin Med. 2000, 25: 57-60.PubMedGoogle Scholar
- Dean JW, Mills PG: Abnormal ventricular repolarization in association with myocardial bridging. Br Heart J. 1994, 71: 366-7. 10.1136/hrt.71.4.366.PubMed CentralView ArticlePubMedGoogle Scholar
- Bestetti RB, Costa RS, Kazava DK, Oliveira JS: Can isolated myocardial bridging of the left anterior descending coronary artery be associated with sudden death during exercise?. Acta Cardiol. 1991, 46: 27-30.PubMedGoogle Scholar
- Ishii T, Hosoda Y, Osaka T, Imai T, Shimada H, Takami A, Yamada H: The significance of myocardial bridge upon atherosclerosis in the left anterior descending coronary artery. J Pathol. 1986, 148: 279-91. 10.1002/path.1711480404.View ArticlePubMedGoogle Scholar
- Ortega-Carnicer J, Fernández-Medina V: Impending acute myocardial infarction during severe exercise associated with a myocardial bridge. J Electrocardiol. 1999, 32: 285-8. 10.1016/S0022-0736(99)90112-7.View ArticlePubMedGoogle Scholar
- Angelini P, Villason S, Chan AV, Diez JG: Normal and anomalous coronary arteries in humans. Coronary artery anomalies: a comprehensive approach. Edited by: Angelini P. 1999, Baltimore: Lippincott Williams & Wilkins, 27-79.Google Scholar
- Gertz SD, Uretsky G, Wajnberg RS, Navot N, Gotsman MS: Endothelial cell damage and thrombus formation after partial arterial constriction: relevance to the role of coronary artery spasm in the pathogenesis of myocardial infarction. Circulation. 1981, 63: 476-86.View ArticlePubMedGoogle Scholar
- Masuda T, Ishikawa Y, Akasaka Y, Itoh K, Kiguchi H, Ishii T: The effect Of myocardial bridging of the coronary artery on vasoactive agents And atherosclerosis localization. J Pathol. 2001, 193: 408-414. 10.1002/1096-9896(2000)9999:9999<::AID-PATH792>3.0.CO;2-R.View ArticlePubMedGoogle Scholar
- Agirbasli M, Martin GS, Stout JB, Jennings HS, Lea JW, Dixon JH: Myocardial bridge as a cause of thrombus formation and myocardial infarction in a young athlete. Clin Cardiol. 1997, 20: 1032-6. 10.1002/clc.4960201213.View ArticlePubMedGoogle Scholar
- Chiappa E, Vineis C: Sudden death during a game of soccer in a young adolescent with a myocardial muscle bridge. G Ital Cardiol. 1993, 23: 473-7.PubMedGoogle Scholar
- Bolli R: The late phase of preconditioning. Circ Res. 2000, 87: 972-83.View ArticlePubMedGoogle Scholar
- Bennett JM, Blomerus P: Thallium-201 scintigraphy perfusion defect with dipyridamole in a patient with a myocardial bridge. Clin Cardiol. 1988, 11: 268-70. 10.1002/clc.4960110414.View ArticlePubMedGoogle Scholar
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