Earlier, Pandey and his group found, an abnormal formation and course of the median nerve in 7% of the cadavers. They found that, the medial root received the communicating branch/branches either from the lateral or posterior cord; both roots of the median nerve were joined on medial side of the axillary artery to form the median nerve. Roots of the median nerve did not join to form the median nerve in the axilla, but, both traveled separately anteromedial to the axillary and brachial arteries . In another study, the median nerve was shown to formed by the fusion of three branches; two from the lateral cord, and one from the medial cord. The abnormal root coming from the lateral cord had very close oblique course over the axillary artery . It has also been shown that, the lateral cord of the brachial plexus after piercing the coracobrachialis and after giving branches to the muscles of the front of the arm, gave one branch as lateral root of the median nerve at the level of the middle of the arm. Later this root joined the medial root to form the median nerve . Goyal and his co-worker found the median nerve to be formed by three roots; the additional root was from the anterior division of the middle trunk . Uzun and his team found median nerve to be formed by four branches, three of them arising from the lateral cord and one from the medial cord . Interestingly, in another study, additional root in the formation of the median nerve was found in 52% of the cases. In 4 cases one of the two lateral roots came from the anterior division of the middle trunk and one from the lateral cord. In 24 cases they found two lateral roots coming from the lateral cord . The lateral and medial roots of the median nerve found to joining in the distal part of the arm rather in the axilla itself [11, 12] and median nerve is also found to fuse with musculocutaneous nerve in the axilla .
Many variations in the relationship of the axillary artery with the roots of the median nerve have been reported. The lateral root of the median nerve found to cross the axillary artery anteriorly and meets the medial root such that the median nerve lies medial to the third part of axillary artery . Das and Paul have observed a similar case where there were two lateral roots of the median nerve .
The subclavian and the axillary system of arteries are derived from the seventh cervical intersegmental artery . Hence, the artery passes between the lateral and the medial cords, representing the fifth, sixth and seventh cervical nerve on the one side and the eighth cervical and first thoracic nerves on the other side. Further, the artery may also arise from the sixth, the eighth or the ninth intersegmental artery leading to abnormal relations with the brachial plexus . Further, the plexus is in turn may modified by the presence of the abnormally placed artery. The segregation of developing structures within the limb bud has a directive action upon the growing nerve fibers and subsequently grouping into definite bundles. The presence of anomalies may be attributed to random factors influencing the mechanism of formation of the limb muscles and the peripheral nerves during embryonic life . Brachial plexus is a routing system to get nerves with common function into the proper terminal nerves. Therefore, errors in the pattern of distribution in the braches of the brachial plexus may finally be corrected distally in the arm, forearm or in the hand before their target innervations .
The knowledge of the variations of the peripheral nervous system is useful in clinical as well as surgical practice as they may be the cause of nerve palsy syndromes, ischemia because of variable relations of nerves with the surrounding muscles and the vessels. The presence of anatomical variations in the peripheral nerves is used to explain unexpected signs and symptoms useful in medical practice. Owing to more reliance on computer imaging in the diagnostic medicine, variations of the brachial plexus are vulnerable to injury during the routine surgical procedures of the axilla  and the upper arm, such as nerve block, cannulation of the axillary vessels during cardiopulmonary bypass , axillary artery perfusion, while transposing and anastomosing the cephalic vein with axillary vein to treat cephalic arch stenosis , internal fixation of humeral fracture, surgical resection of axillary tumors, repair of shoulder dislocation, vessels and nerve repair after trauma, radical mastectomy, lymph node biopsy, lymphodectomy of axilla etc. Anomalous branches and the course of the nerves crossing the axillary artery anteriorly may cause compression syndromes producing ischemia. Further, the knowledge of the possible variations in the brachial plexus seems to be very useful while assessing the same via MRI . Thus, these variations are important to note by the anatomist, clinicians and also by the radiologist.