Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Gastric metaplasia of posterior urethral polyp: a case report

  • 2572 Accesses

  • 1 Citations

Abstract

Congenital polyps of the posterior urethra are rare lesions, and have often been described in boys. The polyps are benign lesion usually lined by a transitional epithelium, but cases of squamous or intestinal metaplasia have been reported.

We report a case of a 10 years old boy referred for hematuria and dysuria.

The voiding cysto urethrogram revealed a filling defect in the posterior urethra. At cystourethroscopy, a polyp of the posterior urethra was found and resected transurethrally. Histological examination showed a polyp with a fibro muscular core covered by focal gastric metaplasia with fundic gland. To our knowledge this is the first reported case of gastric metaplasia of urethral polyp.

Introduction

Urethral polyps are a rare cause of bladder outlet obstruction in the pediatric age group. They are benign fibroepithelial polyps usually diagnosed in the first decade. They have been described often in boys and the posterior urethra is the predominant location [1].

Most patients present with varying degrees of irritative and obstructive voiding symptoms and hematuria [2].

Case presentation

A 10 year old boy was referred to our hospital with complaints of dysuria and hematuria. He had a 6-month history of progressive loss of force and interruption of his urinary stream. He had also a recent history of urinary tract infection treated by antibiotics. Clinical examination and ultrasonography revealed no abnormalities.

A voiding cysto urethrogram showed no reflux or urethral valves but revealed a filling defect in the posterior urethra. Cystourethroscopy revealed the presence of 0,5 cm polyp arising from the posterior urethra. The polyp was resected in its entirety at the base using a 9F resectoscope.

Histopathological examination showed the lesion to be a benign fibroepithelial polyp covered by transitional epithelium with focal areas of gastric metaplasia with fundic glands (figure 1 and 2). Under the epithelium, there was edematous lamina propria with smooth muscle cells. The patient was discharged home two days after surgery, with an uneventful postoperative course. 4 years after surgery, the boy had no urinary symptom and no recurrence.

Figure 1
figure1

Histopathology (original magnification ×100) showing polyp with a fibro muscular core covered by gastric metaplasia with heterotopic fundic glands.

Figure 2
figure2

Histopathology (original magnification ×400) showing fundic glands.

Discussion

Polyps derived from the lower urinary tract are not as frequent when compared with those derived from the upper urinary tract [3]. Polyps of the posterior urethra are rare benign fibro epithelial growths, usually covered by transitional epithelium but cases of squamous or intestinal metaplasia have been reported [4, 5].

The presence of large polyps in healthy newborns and infants is a strong argument in favor of a congenital origin. It has been proposed that they may arise from mesonephric remnants [6].

Concerning metaplasia of the urothelium, three basic types are described: squamous, intestinal, and nephrogenic metaplasia [7].

Intestinal metaplasia of the superficial epithelium of the prostatic urethra was reported, and can be associated with dysplasia [8].

Gastric metaplasia is extremely rare and has been previously recognized in the urothelium of the ureter [9] and the bladder [10], but never in the urethra.

To our knowledge, the present case is the first reported case of urethral gastric heterotopia.

The etiology of the metaplasia of the urothelium is still controversial. Congenital, irritative, infectious, obstructive and traumatic causes have been proposed [4]. Metaplasia is thought to be reactive process to urothelial injury induced by chronic irritation. Maternal estrogen during pregnancy was also thought to be involved [11].

In our observation, gastric metaplasia of the posterior urethral polyp can be linked to obstruction and chronic inflammation.

Transurethral resection has provided an adequate therapeutic approach in this case. Considerable caution must be taken because of the proximity of the external sphincter to the verumontanum.

Other surgical options include Bugbee fulguration of the polyp, laser excision and open suprapubic transvesical excision [6].

Regardless of the treatment, there have been no reported recurrences when the polyp has been removed completely [12].

Consent

Written informed consent was obtained from the parents of the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

References

  1. 1.

    Lamahewage AK, Kelsey A, Gough DC: Urethral polyp in a young girl. Br J Urol. 1998, 82: 456.

  2. 2.

    Brekelbaum CE, Veeramachaneni R, Fontane R, Salard G, Venable DD: Unique management of a congenital polyp of the prostatic urethra. J Urol. 2002, 168: 647-648. 10.1016/S0022-5347(05)64705-2.

  3. 3.

    Williams TR, Wagner BJ, Corse WR, Vestevich JC: Fibroepithelial polyps of the urinary tract. Abdom Imaging. 2002, 27: 217-221. 10.1007/s00261-001-0066-z.

  4. 4.

    Demircan M, Ceran C, Karaman A, Uguralp S, Mizrak B: Urethral polyps in children: a review of the literature and report of two cases. Int J Urol. 2006, 13: 841-843. 10.1111/j.1442-2042.2006.01420.x.

  5. 5.

    Bruijnes E, de Wall JG, Scholtmeijer RJ, den Hollander JC: Congenital polyp of the prostatic urethra in childhood. Report of 3 cases and review of literature. Urol Int. 1985, 40: 287-291.

  6. 6.

    Gentle DL, Kaufman RP, Mandell J: Use of neodymium: yttrium-aluminum-garnet laser for removal of a congenital posterior urethral polyp in a 3-year-old child: a case report and review of the literature. Urology. 1996, 47: 445-447. 10.1016/S0090-4295(99)80472-5.

  7. 7.

    Murphy WM, Beckwith JB, Farrow GM: Tumors of the kidney, bladder and related structures. Atlas of tumor pathology, 3rd series, fascicle 11. 1994, The Armed forces institute of pathology, Washington DC

  8. 8.

    Maung R, Kelly JK, Grace DA: Intestinal metaplasia and dysplasia of prostatic urethra secondary to stricture. Urology. 1988, 32: 361-363. 10.1016/0090-4295(88)90246-4.

  9. 9.

    Nasu M, Hamasaki K, Kishi H, Matsubara O: Nephrogenic adenoma of the ureter with gastric metaplasia. J Urol Pathol. 1997, 7: 63-69.

  10. 10.

    Soulie M, Mouly P, Plante P, Escourrou G, Pontonier F: Primary bladder signet ring cell adenocarcinoma. A propos of 1 case. Review of the literature. Prog Urol. 1993, 3: 677-682.

  11. 11.

    Kuppusami K, Moors DE: Fibrous polyp of the verumontanum. Can J Surg. 1968, 11: 388-391.

  12. 12.

    Spyropoulos C, Konidaris D, Papanicolaou A, Stephanidis A, Michael V, Androulakakis PA: Posterior urethral polyp in a boy, diagnosed by colour Doppler ultrasonography. BJU Int. 1999, 84: 881-882. 10.1046/j.1464-410x.1999.00336.x.

Download references

Author information

Correspondence to Mehdi Jaidane.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

MJ and AH collected the data and literature review, and wrote the manuscript. AS, WH and NBS revised and provided comments on the manuscript. FM was the attending doctor, carried out the surgical procedure and literature review. All authors read and approved the final manuscript.

Authors’ original submitted files for images

Below are the links to the authors’ original submitted files for images.

Authors’ original file for figure 1

Authors’ original file for figure 2

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Jaidane, M., Hidoussi, A., Slama, A. et al. Gastric metaplasia of posterior urethral polyp: a case report. Cases Journal 2, 9119 (2009). https://doi.org/10.1186/1757-1626-2-9119

Download citation

Keywords

  • Intestinal Metaplasia
  • Bladder Outlet Obstruction
  • Fundic Gland
  • Prostatic Urethra
  • Transitional Epithelium