- Case Report
- Open Access
Benign mesenteric lymphangioma presenting as acute pancreatitis: a case report
© Akwei et al; licensee BioMed Central Ltd. 2009
Received: 8 November 2009
Accepted: 16 December 2009
Published: 16 December 2009
Benign mesenteric lymphangiomas are rare intra-abdominal cysts which may be asymptomatic or present with a variety of abdominal symptoms including an acute abdomen. We are however not aware of any reports in the literature linking mesenteric lymphangioma to acute pancreatitis. We present the case of a 62-year-old man who was admitted with signs and symptoms of acute pancreatitis and a palpable abdominal mass. Computerised tomography (CT) of his abdomen confirmed the presence of a mesenteric cystic mass. He underwent a laparotomy at which a large thin walled mass filled with a chylous fluid was resected. Histological analysis of this cyst showed it to be a benign mesenteric lymphangioma.
In the early post-operative period, he made good progress but began showing signs of infection, with rising infection markers, pyrexia and abdominal discomfort. A CT scan of the abdomen revealed a pelvic collection requiring a CT-guided drain. This collection was purulent in appearance, and Escherichia coli was cultured from it. He settled symptomatically with drainage of the collection and antibiotic treatment, and was subsequently discharged three weeks later. He represented one month after discharge with a recurrent intra-abdominal collection which also necessitated CT guided drain. There was no further recurrence of a collection after this. No recurrence of the cyst has been noted after a year of follow-up.
A diagnosis of acute pancreatitis should be considered in a patient presenting with acute abdominal pain, nausea and vomiting. The cause of pancreatitis is diverse but is often associated with gallstone disease or excess alcohol and can be discerned from the history and initial laboratory investigations. Other more obscure causes require further investigation. Approximately 10% are said to have idiopathic pancreatitis, where no obvious case is found .
Our patient presented with typical symptoms of acute pancreatitis. He had evidence of peripancreatic inflammation on his CT scan and elevated serum amylase. Abdominal ultrasonography and CT also did not show demonstrate gallstones. Other liver function tests were not consistent with gallstone disease and he did not have a history of alcohol excess. Intra-operatively, the mass was found to be adherent to the head of the pancreas.
Benign mesenteric lymphangiomas are rare intra-abdominal cysts thought to account for between 1 in 100,000 to 1 in 250,000 of hospital admissions [2, 3]. Lymphangiomas in general are commoner in children, 40% usually present by age 1 and 80% by age 5 . It is thus unusual for lymphangioma to be seen in an older adult as in our case. Lymphangiomas can occur throughout the body but commonest site is usually the neck, where they are referred to as cystic hygromas. Within the abdomen, the commonest site is the mesentery [4, 5] but may also occur in the omentum, retroperitoneum and mesocolon [5, 6]. Lymphangiomas of the pancreas has also been reported .
The aetiology of lymphangiomas remains unclear. Congenital developmental defects of the lymphatics have been proposed, such as the proliferation and dilatation of blind ended lymphatic sacs which lack proper connections with the venous system . The theory of a congenital aetiology may be supported by the fact that most cases present in childhood. Other potential causes are thought to include, abdominal trauma, localised lymphatic degeneration and lymphatic obstruction [8, 9].
Clinically, intra-abdominal lymphangiomas may be asymptomatic; however a gradual increase in abdominal girth, sensation of fullness and vague abdominal pain should alert the clinician of this rare condition. Pain may range from chronic background abdominal pain to more acute pain due to torsion or haemorrhage into the cyst, compression of surrounding structures or intestinal obstruction. They can also infiltrate into surrounding viscera and lead to organ dysfunction . Although cystic lymphangiomas of the pancreas have been reported , we are not aware of any reports of mesenteric lymphangioma presenting as acute pancreatitis as in our case. It is likely that the part of the cyst found to be adherent to the pancreas caused pancreatitis through compression or local irritation.
The diagnosis of mesenteric lymphangioma is usually made histologically following surgical resection of the cyst. There are no blood tests which will confirm the diagnosis. Radiological investigations using ultrasound or computerised tomography (CT) usually confirms the presence of a mass and may help to exclude other causes of intra-abdominal masses but is usually insufficient to provide a definite diagnosis. MRI has also been proposed as a suitable investigation for defining the origins of the mass and thus aid diagnosis . However, Jain et al report using multislice spiral CT to confidently establish a diagnosis prior to surgery .
Treatment of mesenteric cysts is primarily by surgical resection. This has traditionally been through open surgery, however laparoscopic resection has been reported . Occasionally resection of adjacent structures such as small bowel may also be required where the cyst intimately involves the bowel or important vessels. In our case the cyst wall was adherent to the pancreas, thus making complete resection impossible without damage to the pancreas. It is likely that the remnant of the cyst wall may have contributed to the recurrent collections our patient developed following his surgery. The use of alcohol  and OK432  have also been reported as an alternative is cases where surgical resection is not a viable option.
Our case illustrates an unusual presentation of benign lymphangioma and options for treatment. Although rare, clinicians should consider mesenteric lymphangioma in the differential diagnoses of patients found to have intra-abdominal cystic masses on abdominal CT scans.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors will like to thank Dr Lorraine Sheehan, Consultant Histoplathologist, for her contribution in providing the histology images and descriptions.
- Russell RCG: The Pancreas. Bailey and Loves' Short Practice of Surgery. Edited by: Russell RCG, Williams NS, Bulstrode CJK. 2004, London: Hodder Arnold, 1115-1132. 24Google Scholar
- Chim H, Chuwa E, Chau Y-P, Chow PK: Gastrointestinal: Mesenteric cystic lymphamgioma. J Gastroenterol Hepatol. 2006, 21: 916-10.1111/j.1440-1746.2006.04479.x.View ArticlePubMedGoogle Scholar
- Campbell WJ, Irwin ST, Biggart JD: Benign lymphangioma of the jejunal mesentery: an unusual cause of small bowel obstruction. Gut. 1991, 32: 1568-10.1136/gut.32.12.1568.PubMed CentralView ArticlePubMedGoogle Scholar
- Weeda VB, Booij KAC, Aronson DC: Mesenteric cystic lymphangioma: a congenital and an acquired anomaly? Two cases and a review of the literature. J Pediatr Surg. 2008, 43: 1206-1208. 10.1016/j.jpedsurg.2008.01.075.View ArticlePubMedGoogle Scholar
- Stein M, Hsu RK, Schneier PD, Ruebner BH, Mina Y: Alcohol ablation of a mesenteric lymphangioma. JVIR. 2000, 11: 247-250.View ArticlePubMedGoogle Scholar
- Miliaras S, Trygonis S, Papandoniou A, Kalamaras S, Trygonis C, Kiskinis D: Mesenteric cyst of the descending colon: Report of a case. Acta Chir Belg. 2006, 106: 714-716.PubMedGoogle Scholar
- Koenig TR, Loyer EM, Whitman GJ, Raymond AK, Charnsangavej C: Cystic lymphangioma of the pancreas. AJR Am J Roentgenol. 2001, 177: 1090.View ArticlePubMedGoogle Scholar
- Losanoff JE, Richman BW, El-Sherif A, Rider KD: Mesenteric Cystic Lymphangioma. J Am Coll Surg. 2003, 196 (4): 598-603. 10.1016/S1072-7515(02)01755-6.View ArticlePubMedGoogle Scholar
- Chen CW, Hsu SD, Cheng MF, Yu JC: Cystic lymphangioma of the jejunal mesentery in an adult: A case report. World J Gastroenterol. 2005, 11 (32): 5084-5086.PubMed CentralView ArticlePubMedGoogle Scholar
- Jain S, Upreti L, Bhargava SK, Gupta R, Gupta PK: Mesenteric lymphangioma: diagnosis by multislice spiral CT [Letter]. Indian J Radiol Imaging. 2002, 12: 580-582.Google Scholar
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