Arthrogryposis multiplex congenital (AMC) in a three year old boy: differential diagnosis with distal arthrogryposis: a case report
Cases Journal volume 2, Article number: 9403 (2009)
Arthrogryposis multiplex congenital (AMC) is characterized by contractions of multiple joints present at birth. The involved muscles are partially or totally replaced by fat or fibrous tissue. Talipes equinovarus and scoliosis are also frequently reported.
This 2 year was born after uneventful pregnancy, with normal birth weight and length. The parents are unrelated, young and healthy. No malformations or mental retardation have been reported in the family. Since his birth a specific posture was noted: internal rotation at the shoulders, extension at the elbows, and flexion at the wrists. In addition, the child has a severe equinovarus deformity of the feet. Syndactily between II and III finger was also noted. His face is round with a frontal midline capillary hemangioma, while his jaw appears to be small. Mental development is normal. The karyotype is: 46, XY.
About 150 syndromes have arthrogryphosis as a presenting sign. AMC is a distinct entity and distinction with the distal forms of arthrogryphosis can be difficult, since there is a considerable clinical and genetic heterogeneity. A comprehensive musculoskeletal evaluation and genetic consultation is necessary.
Stiff joints present from birth (arthrogryphosis) are a frequent clinical finding. The frequency of the phenomenon stems from the fact that arthrogryphosis can be a syndrome per se, or it can be a part of many other syndromes, malformations or muscular or neurological conditions. Such a vast clinical diversity is accompanied, at least in some of those specific conditions by a remarkable genetic heterogeneity. In some of the characteristic clinical forms the diagnosis is straightforward. In others, finding a precise diagnosis can be a challenge. The different treatments for particular conditions, as well as the possibility for genetic counseling for some of the arthrogryphosis conditions render the very precise diagnosis necessity.
We here present a child with arthrogryphosis congenital multiplex (AMC) and its delineation from the other arthrogryphosis conditions, in particular with the syndromes of the distal arthrogryphosis (DA).
This 2 year old boy was diagnosed with AMC at the age of 10 months. He was born after uneventful pregnancy, with normal birth weight and length. The parents are unrelated, young and healthy, and the family does not have a history of malformations or mental retardation. A peculiar body posture is evident: internal rotation at the shoulders, extension at the elbows, and flexion at the wrists. A severe equinovarus deformity of the feet and syndactily between II and III finger are also present. A frontal facial midline capillary hemangioma, and a small jaw are also present. His mental development is normal retarded. Ultrasound of the kidneys is uneventful. Creatinin kinase concentrations in serum were normal. Karyotype is normal male: 46, XY. Radiography revealed scoliosis and talipes equinovarus.
Since the first descriptions  AMC was described as limited flexion of joints of the arms and neck and with absent flexion creases of the fingers. In addition, talipes equinovarus and scoliosis and were also reported. In a review article, Hall et al. (1983) found congenital contracture syndrome in 135 of 350 patients. An early observation included a specific positioning present at birth with internal rotation at the shoulders, extension at the elbows, and flexion at the wrists. Severe equinovarus deformity of the feet is frequently present . A frontal midline capillary hemangioma, small jaw, round face and normal intelligence are also found to be typical. Twins have been described, but the condition is mainly sporadic. Our patient has all the features belonging to the AMC. In addition, since no other family member has joint contractures or a malformation our child is a sporadic case of AMC.
Besides the classic AMC, other distinct types of X-linked arthrogryposis have been described. DA1 is a distal form of AMC characterized by autosomal dominant inheritance, intrafamilial variability and involvement primarily of the hands and feet. The position of the hands is specific: the fingers are medially overlapping and ulnarly deviated, the fists are clenched. No associated visceral anomalies have been reported, while the intelligence is normal [3, 4].
Distal arthrogryposis type 2B is a clinically and genetically heterogeneous disorder characterized by clenched fist, overlapping fingers, camptodactyly, ulnar deviation, and positional foot deformities from birth. This type of distal arthrogryphosis can be caused by mutations in TNN3 gene which encodes tropinin T and I.
DA2B shares features with DA1 and Freeman-Sheldon syndrome (FSS), also known as DA2A [5–7]. DA2B is characterized by contractures of the fingers, toes, wrist, ankles, knees, and elbows with a lack of interphalangeal creases and bilateral ptosis [3, 8]. Later, Bamshad et al. (1996) renamed this form of DA as DA5 .
There is a considerable genetic heterogeneity among various forms of DA. Sung et al. (2003) reported that DA1 can be caused by mutation of the TPM2, the gene encoding beta-tropomyosin, while DA2B can be caused by mutations in the TNNI2 gene, which encodes an isoform of troponin I [10, 11]. The distal arthrogryposis type 2A can be caused by mutation in the MYH3 gene. Mutations in this gene can also cause distal arthrogryposis type 2B (DA2B), also known as Sheldon-Hall syndrome. An abnormal x-ray appearance of the floor of the anterior cranial fossa of the skull, and facial characteristics withe deep-sunken eyes, hypertelorism, increased philtrum length, small nose and nostrils, and a small mouth are a specific distinction of this DA type . Bamshad et al. (1996) denoted Freeman-Sheldon syndrome as DA2 (later DA2A).
DA2A which includes in its phenotype ptosis, dwarfism, small contracted mouth, and proximal and distal joint contractures was found to have MYH3 gene mutations. On the other hand, Toydemir et al. (2006) found a mutation in the MYH3 gene in 26 of 28 FSS cases .
Another form of DA, DA2E, characterized by small mouth and jaw with limited jaw movement, with horizontal depression above the chin, microcephaly and severe flexion contractures of the hands and feet [3, 12].
Congenital contractural arachnodactyly (CCA) is a rare, autosomal dominant disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears with overlapping features with Marfan syndrome. Wang et al. (1995) identified point mutations in the FBN2 gene in cases of CCA . Bamshad et al. (1996) referred to this disorder as distal arthrogryposis type 9 (DA9).
Arthrogryposis multiplex congenita can also have neurogenic origin. This form of arthrogryphosis is also genetically heterogeneous. It includes a subgroup which is allelic to spinal muscular atrophy type I, or Werdnig-Hoffmann disease (SMA1).
Some AMC forms are mild  and limited to the lower extremities, others (DA 10) have only short tendo calcaneus [16, 17]. DA5 is arthrogryposis with oculomotor limitation and electroretinal abnormalities , DA4 (DAIID) is a form with severe scoliosis . AMC can also be of neurogenic type, resulting from GLE1 gene mutations , or can have a specific whistling face (Illum syndrome).
AMC is a distinct entity that needs to be delineated from the other arthrogryphosis types (~10 types so far) and other syndromes in which stiff joints are a part of the phenotype (~150 syndromes). In particular, the distinction with the distal forms of arthrogryphosis can be challenging. A considerable clinical and genetic heterogeneity is noted in almost all arthrogryphosis types. Therefore, a comprehensive musculoskeletal evaluation and genetic consultation is necessary.
Written informed consent was obtained from the father of the patient for publication of this case report.
Lacassie Y, Sack GH, McKusick VA: An autosomal dominant form of arthrogryposis multiplex congenita (AMC) with unusual dermatoglyphics. (Abstract). Birth Defects Orig Art Ser. 1977, XIII (3B): 246-247.
Hall JG, Reed SD, Driscoll EP: Part 1. Amyoplasia: a common, sporadic condition with congenital contractures. Am J Med Genet. 1983, 15: 571-590. 10.1002/ajmg.1320150407.
Hall JG, Reed SD, Greene G: The distal arthrogryposes: delineation of new entities--review and nosologic discussion. Am J Med Genet. 1982, 11: 185-239. 10.1002/ajmg.1320110208.
Daentl DL, Berg BO, Layzer RB, Epstein CJ: A new familial arthrogryposis without weakness. Neurology. 1974, 24: 55-60.
Krakowiak PA, O'Quinn JR, Bohnsack JF, Watkins WS, Carey JC, Jorde LB, Bamshad M: A variant of Freeman-Sheldon syndrome maps to 11p15.5-pter. Am J Hum Genet. 1997, 60: 426-432.
Shrimpton AE, Hoo JJ: A TNNI2 mutation in a family with distal arthrogryposis type 2B. Europ J Med Genet. 2006, 49: 201-206. 10.1016/j.ejmg.2005.06.003.
Kimber E, Tajsharghi H, Kroksmark A-K, Oldfors A, Tulinius M: A mutation in the fast skeletal muscle troponin I gene causes myopathy and distal arthrogryposis. Neurology. 2006, 67: 597-601. 10.1212/01.wnl.0000230168.05328.f4.
Friedman BD, Heidenreich RA: Distal arthrogryposis type IIB: further clinical delineation and 54-year follow-up of an index case. Am J Med Genet. 1995, 58: 125-127. 10.1002/ajmg.1320580207.
Bamshad M, Jorde LB, Carey JC: A revised and extended classification of the distal arthrogryposes. Am J Med Genet. 1996, 65: 277-281. 10.1002/(SICI)1096-8628(19961111)65:4<277::AID-AJMG6>3.0.CO;2-M.
Sung SS, Brassington A-ME, Grannatt K, Rutherford A, Whitby FG, Krakowiak PA, Jorde LB, Carey JC, Bamshad M: Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes. Am J Hum Genet. 2003, 72: 681-690. 10.1086/368294.
Sung SS, Brassington A-ME, Krakowiak PA, Carey JC, Jorde LB, Bamshad M: Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B. (Letter). Am J Hum Genet. 2003, 73: 212-214. 10.1086/376418.
Hall JG, Truog WE, Plowma DL: A new arthrogryposis syndrome with facial and limb anomalies. Am J Dis Child. 1975, 129: 120-122.
Toydemir RM, Rutherford A, Whitby FG, Jorde LB, Carey JC, Bamshad MJ: Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Nature Genet. 2006, 38: 561-565. 10.1038/ng1775.
Wang M, Tsipouras P, Godfrey M: Fibrillin-2 (FBN2) mutation in congenital contractural arachnodactyly. (Abstract). Am J Hum Genet. 1995, 57: A231.
Zori RT, Gardner JL, Zhang J, Mullan MJ, Shah R, Osborn AR, Houlden H, Wallace MR, Roberts S, Yang TP: Newly described form of X-linked arthrogryposis maps to the long arm of the human X chromosome. Am J Med Genet. 1998, 78: 450-454. 10.1002/(SICI)1096-8628(19980806)78:5<450::AID-AJMG10>3.0.CO;2-E.
Levine MS: Congenital short tendo calcaneus. Am J Dis Child. 1973, 125: 858-859.
Stevenson DA, Swoboda KJ, Sanders RK, Bamshad M: A new distal arthrogryposis syndrome characterized by plantar flexion contractures. Am J Med Genet. 2006, 140A: 2797-2801. 10.1002/ajmg.a.31528.
Beals RK, Weleber RG: Distal arthrogryposis 5: a dominant syndrome of peripheral contractures and ophthalmoplegia. Am J Med Genet. 2004, 131: 67-70. 10.1002/ajmg.a.30289.
Nousiainen HO, Kestila M, Pakkasjarvi N, Honkala H, Kuure S, Tallila J, Vuopala K, Ignatius J, Herva R, Peltonen L: Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease. Nature Genet. 2008, 40: 155-157. 10.1038/ng.2007.65.
Illum N, Reske-Nielsen E, Skovby F, Askjaer SA, Bernsen A: Lethal autosomal recessive arthrogryposis multiplex congenita with whistling face and calcifications of the nervous system. Neuropediatrics. 1988, 19: 186-192. 10.1055/s-2008-1052443.
The authors declare that they have no competing interests.
All of the authors were involved in the clinico-radiographic assessment and finalizing the paper. All authors have red and approved the final version of the paper.
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Gucev, Z.S., Pop-Jordanova, N., Dumalovska, G. et al. Arthrogryposis multiplex congenital (AMC) in a three year old boy: differential diagnosis with distal arthrogryposis: a case report. Cases Journal 2, 9403 (2009). https://doi.org/10.1186/1757-1626-2-9403
- Spinal Muscular Atrophy
- Normal Birth Weight
- MYH3 Gene
- Spinal Muscular Atrophy Type
- Arthrogryposis Multiplex Congenital