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A 55-year-old craftsman with dyspnea and clubbing: a case report
Cases Journal volume 2, Article number: 8579 (2009)
Abstract
Introduction
Clubbing is very uncommon in respiratory bronchiolitis-associated interstitial lung disease, and primarily raises the suspicion of idiopathic pulmonary fibrosis in a patient presenting with diffuse parenchymal lung disease. If idiopathic pulmonary fibrosis can be excluded, clubbing should raise the suspicion of an occult tumour.
Case presentation
We describe a heavy smoker presenting with dyspnea and severe clubbing. Surgical lung biopsy revealed the histologic diagnosis of respiratory bronchiolitis-associated interstitial lung disease. Respiratory bronchiolitis-associated interstitial lung disease is a distinct clinicopathologic entity within idiopathic interstitial pneumonia patients described almost exclusively in cigarette smokers. The disease is associated with a good prognosis and mild symptoms but not with clubbing. After smoking cessation the radiologic findings of interstitial lung disease improved in parallel with improvement in lung function and gas exchange. However, a central squamous cell carcinoma was detected in the follow-up.
Conclusion
In this case, clubbing was most probably caused by the occult tumor rather than by respiratory bronchiolitis-associated interstitial lung disease.
Introduction
Cigarette smoking is a well-recognized cause of a variety of lung diseases, including interstitial lung disease. Clubbing in itself is very uncommon in respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), and primarily raises the suspicion of idiopathic pulmonary fibrosis (IPF) in a patient presenting with diffuse parenchymal lung disease (ILD). If IPF is excluded histologically, clubbing should raise the suspicion of an occult tumour such as non small cell lung cancer.
Case presentation
A 55-year-old Caucasian who had been a heavy smoker (up to 40 cigarettes per day) over 37 years reported to our outpatient clinic because of increasing dyspnea and persistent cough. He had been working as craftsman for 35 years with a history of exposure to cement dust, but not to birds or other animals, fungi or other organic fine particles. He did not report weight loss, sweat or fever. On examination he had normal vital signs and was comfortable at rest. Extremities showed considerable clubbing of fingers (Figure 1) and toes. Chest examination revealed fine inspiratory basal crackles. Laboratory testing revealed a normal red and white blood count (Hb 15 g/dL; WBC 9.7 × 103/µL), and a normal differential WBC (0% Eosinophils) and platelet count (331 × 103/µL). Routine clinical chemistry was within the normal range, IgG, rheumatoid factor, antinuclear antibodies and anticytoplasmatic antibodies were all negative, IgE, ACE, NT-proBNP and α-1-antitrypsin levels were within the normal range. A room air arterial blood gas analysis showed pH 7.4; PaO2 80 mm Hg; PaCO2 40 mm Hg; O2Sat 96 %; HCO3 24 mEq/L; resting alveolar-arterial oxygen tension gradient 21.5 mm Hg. The echocardiogram was normal. Chest radiograph showed reticulonodular infiltrates in both lung bases. HRCT showed diffuse ground glass opacities predominantly involving the lung bases, and subpleural fibrosis (Figure 2). There was one central irregular opacity of 1.5 cm in diameter which was planned for biopsy. Pulmonary function test (PFT) showed: FEV1 2.26 L (65% pred); FVC 2.42 L (56% pred); FEV1/FVC 94%; a total lung capacity (TLC) of 81% predicted, and residual volume of 124%; diffusing capacity of the lung for carbon monoxide (DLCO) 4 mmol/min/kPa (45% pred), consistent with a mild to moderate obstruction, a moderate restriction, and a moderate to severe diffusion abnormality. By means of video assisted thoracoscopy, peripheral wedge resections were taken from two lobes. These showed abundant pigment-laden intraalveolar macrophages in patchy aggregates, predominantly in the lumen of the bronchioles but extending into the alveolar space at multiple foci, following a peribronchial distribution (Figure 3). There was thickening of the bronchiolar walls by smooth muscle hypertrophy and mild edema, but no evidence of alveolar interstitial fibrosis, and no evidence of lung cancer. These histologic findings, together with the clinical features were interpreted as RB-ILD. A biopsy of the central opacity showed fibrotic organisation without signs of malignancy. The patient was advised to quit smoking. On the day before surgical procedure the patient stopped smoking and did not start again. No other measures were taken after the lung biopsy. After 10 months of non-smoking, his symptoms had improved and he was able to perform his daily activities without dyspnea. Repeated PFT´s and radiography showed slight improvement. On the CT control there was some improvement in the interstitial changes, however, the central nodule had grown to 1.7 cm in diameter, and a CT-guided needle biopsy revealed a squamous cell carcinoma (Figure 4), which, at that point, was not operable. The patient was staged and chemotherapy was applied for the following 18 months, until the patient died, 42 months after initial presentation.
Discussion
Cigarette smoking is a well-recognized cause of a variety of lung diseases, including interstitial lung disease [1]. Although RB-ILD is regarded as one manifestation of the parenchymal response to cigarette smoke inhalation in both animals and humans [2, 3], the pathologic mechanisms are poorly understood. RB-ILD is associated with interstitial edema and intraalveolar macrophage accumulation, a key feature of interstitial inflammation [4]. Most patients with RB-ILD are either asymptomatic or describe only mild symptoms, they are typically young (mean age 36 years), with an average of 30 to 40 years of smoking history [5]. When present, symptoms include minimally productive cough and dyspnea. Physical signs include late inspiratory crackles, but no velcro rales. RB-ILD has a much better outcome than other forms of idiopathic interstitial pneumonia [6], and it is important to establish this diagnosis because of its significantly better prognosis, and to avoid unnecessary treatment with potentially toxic medications. Clubbing in itself is very uncommon in RB-ILD [4, 7, 8], with an incidence ranging from 12.5% to 33 % [9, 10], and primarily raises the suspicion of idiopathic pulmonary fibrosis in a patient presenting with DPLD, or lung cancer. It is important to keep this in mind, and to start diagnostic approaches as soon as possible, since a timely delay of diagnosis, reported as high as up to 4 months from clinical presentation of digital clubbing to the final diagnosis of lung cancer [11], may have impact on therapy and prognosis.
Consent
Written informed consent could not be obtained from the patient for publication of this case report and accompanying images since the patient deceased, and there are no relatives.
Abbreviations
- DLCO:
-
diffusing capacity of the lung for carbon monoxide
- HRCT:
-
high-resolution computed tomography
- IPF:
-
idiopathic pulmonary fibrosis
- PFT:
-
pulmonary function test
- RB-ILD:
-
respiratory bronchiolitis-associated interstitial lung disease
- TLC:
-
total lung capacity.
References
Steele MP, Speer MC, Loyd JE, Brown KK, Herron A, Slifer SH, Burch LH, Wahidi MM, Phillips JA, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA: Clinical and Pathologic Features of Familial Interstitial Pneumonia. Am J Respir Crit Care Med. 2005, 172: 1146-1152. 10.1164/rccm.200408-1104OC.
Hammond EC, Auerbach O, Kirman D, Garfinkel L: Effects of cigarette smoking on dogs. Arch Environ Health. 1970, 21: 740-753.
Weiss W: Cigarette smoking and diffuse pulmonary fibrosis. Am Rev Respir Dis. 1969, 99: 67-72.
Yousem SA, Colby TV, Gaensler EA: Respiratory bronchiolitis-associated interstitial lung disease and its relationship to desquamative interstitial pneumonia. Mayo Clin Proc. 1989, 64: 1373-1380.
Myers JL, Veal CF, Shin MS, Katzenstein AL: Respiratory bronchiolitis causing interstitial lung disease. A clinicopathologic study of six cases. Am Rev Respir Dis. 1987, 135: 880-884.
Carrington CB, Gaensler EA, Coutu RE, FitzGerald MX, Gupta RG: Natural history and treated course of usual and desquamative interstitial pneumonia. N Engl J Med. 1978, 298: 801-809. 10.1056/NEJM197804132981501.
King TE: Respiratory bronchiolitis-associated interstitial lung disease. Clin Chest Med. 1993, 14: 693-698.
Moon J, du Bois RM, Colby TV, Hansell DM, Nicholson AG: Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax. 1999, 54: 1009-1014. 10.1136/thx.54.11.1009.
Portnoy J, Veraldi KL, Schwarz MI, Cool CD, Curran-Everett D, Cherniack RM, King TE, Brown KK: Respiratory bronchiolitis-interstitial lung disease: long-term outcome. Chest. 2007, 131: 664-671. 10.1378/chest.06-1885.
Sadikot RT, Johnson J, Loyd JE, Christman JW: Respiratory bronchiolitis associated with severe dyspnea, exertional hypoxemia, and clubbing. Chest. 2000, 117: 282-285. 10.1378/chest.117.1.282.
Koyi H, Hillerdal G, Branden E: Patient's and doctor's delays in the diagnosis of chest tumours. Lung Cancer. 2002, 35: 53-75. 10.1016/S0169-5002(01)00293-8.
Sridhar KS, Lobo CF, Altman RD: Digital Clubbing and Lung Cancer. Chest. 1998, 114: 1535-1537. 10.1378/chest.114.6.1535.
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Authors' contributions
SS and GK were the major contributors in writing the manuscript. ES performed the histological examination. HP reviewed the histological examination. HO did the final review. All authors read and approved the final manuscript.
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Scheidl, S., Kovacs, G., Stacher, E. et al. A 55-year-old craftsman with dyspnea and clubbing: a case report. Cases Journal 2, 8579 (2009). https://doi.org/10.4076/1757-1626-2-8579
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DOI: https://doi.org/10.4076/1757-1626-2-8579
Keywords
- Idiopathic Pulmonary Fibrosis
- Interstitial Lung Disease
- Idiopathic Interstitial Pneumonia
- Occult Tumour
- Surgical Lung Biopsy