- Case Report
- Open Access
Spontaneous regression of a true splenic cyst: a case report and review of the literature
© Stoidis et al.; licensee Cases Network Ltd. licensee BioMed Central Ltd. 2009
- Received: 21 July 2009
- Accepted: 31 August 2009
- Published: 16 September 2009
Splenic cysts are rare clinical findings, detected due to derivative symptoms or as a random discovery in abdominal imaging. Although there still remains controversy as to their optimal treatment, bigger secondary cysts should be treated surgically. However, spontaneous regression may be observed in cysts with a diameter smaller than 4 cm. In these cases, expectant treatment is preferable. We report, herein, a single case of a splenic cyst in an adult woman, who reported minor symptoms despite the size of the lesion and who demonstrated a possible almost total regression of the cyst within a ten-year period, accompanying with review of the most recent literature.
- Cyst Wall
- Cavernous Hemangioma
- Splenic Cyst
- Partial Splenectomy
Cystic lesions of the spleen have been recognized with increasing frequency since the advent of CT scanning and ultrasound imaging . Splenic cysts are classified as true or false cysts, and they may be either nonparasitic or parasitic, and pseudocysts. Cyst-appearing tumors of the spleen include cystic lymphangiomas and cavernous hemangiomas. Primary true cysts of the spleen account for about 10% of all nonparasitic cysts of the spleen . On the other hand, most nonparasitic cysts are pseudocysts and are secondary to trauma. The diagnosis of true splenic cysts is commonly made in the 2nd and 3rd decades of life . True cysts are characterized by a squamous epithelial lining, and many are considered congenital. These epithelial cells are often positive for CA 19-9 and CEA by immunochemistry, and patients with epidermoid cysts of the spleen may have elevated serum levels of one or both of these tumor-associated antigens . Despite the presence of these tumor markers, these cysts are benign and apparently do not have malignant potential greater than any other native tissue.
A 42-year-old overweight woman from rural Greece visited the local physician in February 1997 reporting several episodes of mild upper abdominal pain during the previous three years, not related to food consumption. The pain was not observed elsewhere on the body nor was it correlated with other symptoms, such as fever, nausea or vomiting. In addition, the pain did not affect food intake or daily physical activity. Before medical consultation no systematic treatment had been applied for the pain, which was relieved after some minutes, only to relapse some days later.
Surprisingly, in our case, the cyst, although particularly large, was only reported to cause mild symptoms though were not definitely linked to the finding itself, which may imply that former empirical treatment rules may not be applicable in all such cases after all.
Splenic cysts are generally uncommon clinical findings. They are classically categorized as primary and secondary. Primary (true) cysts have a complete epithelial wall, which may be related to infections (mostly parasites), neoplasms or congenital abnormalities. On the other hand, secondary cysts (pseudocysts) are mostly posttraumatic findings, but special infections and infracts are also likely causes. Although no complete registry of cases described so far is available, it has been estimated that about 800 cases have been diagnosed internationally. Of these, the large majority refers to parasitic cysts, although these are rare in developed countries. The remaining cases of non-parasitic cysts are about 300, described by numerous departments in small numbers . The etiology of the splenic cysts is not always easy to determine. The general tendency is to exclude the usual and simpler diagnoses, i.e. infectious and traumatic lesions, before examining more rare possibilities, such as cystic neoplasms.
Often, true splenic cysts are asymptomatic and found incidentally. When symptomatic, patients may complain of vague upper abdominal fullness and discomfort, early satiety, pleuritic chest pain, shortness of breath, left back or shoulder pain, or urinary symptoms due to compression of the left kidney. A palpable abdominal mass may be present. The presence of clinical manifestation has been related to cyst position, type and size. As far as the latter criterion is concerned, scientific opinion varies, but 4 cm or bigger lesions are practically unanimously viewed as potentially symptomatic . Rarely, these cysts may present with acute symptoms related to rapture, hemorrhage or infection. The diagnosis of splenic cysts is best established with CT imaging.
Which cysts should be operated and which should be treated conservatively?
ii) Is open or laparoscopic approach the treatment of choice?
The answers provided so far have been based on recent clinical experience and concluded that rupture is more likely in lesions exceeding 4-5 cm in diameter, thus setting this size as the minimal indication for asymptomatic cyst operative treatment . As far as the approach is concerned, this is primarily based on the experience of the center and available means, but generally, laparoscopy, where available and applied at a routine basis, offers comparable results, limiting surgical time, complications and post-operative hospitalization of the patient [11, 12].
Operative intervention is indicated for symptomatic cysts and for large cysts. Either total or partial splenectomy may provide successful treatment. If the cyst is very large and almost completely covered by splenic parenchyma, or if it is located in the splenic hilum, complete splenectomy is recommended, because of the risk of intractable bleeding from the spleen.
The clear advantage of partial splenectomy is the preservation of splenic function . Preservation of at least 25% of the spleen appears sufficient to protect against pneumococcal pneumonia. Most recent reports describe successful experience with partial splenectomy, cyst wall resection, or partial decapsulation, which may be accomplished with either an open or laparoscopic approach . Partial splenectomy is recommended, if the cyst is located at the poles of the spleen, or if the cyst cavity is deep, due to the higher risk of recurrence . Incision of the splenic capsule and hemostasis is performed with the ultrasonic or the monopolar scissors. A more conservative option could be a partial cystectomy (unroofing) of the cyst. However, it has yet to be determined how much of the cyst wall should be resected, and whether unroofing should be partial or radical. It is supported that as much of the cyst wall as possible should be resected to prevent reclosure of the cyst .
In our case, neither patient history nor all further evaluation, i.e. clinical, laboratory and imaging alike, succeeded in attributing the cyst to any of the more possible causes. Thus, the exact etiology remains indeterminate and the idea of a congenital lesion remaining unnoticed for 5 decades, seems to be very possible.
The physical history of splenic cysts may include all imaginable scenarios, i.e. stability, growth, rupture or involution. The latter was the case in our patient. However, relevant experience has stated that this outcome is more probable in congenital cysts during fetal and neonatal life or in adults with non-parasitic cysts (especially pseudocysts) smaller than 5 cm and within an observation period of up to 36 months -. However, our current case report indicates that this clinical rule is not always accurate in the prediction of clinical outcome, since a ten-year follow-up showed no signs of rupture, despite the original size of the lesion.
Our finding is therefore unique, since it refers to a possibly latent congenital epithelial cyst of relatively large original dimensions, which still reached almost total regression within a 10-year period. This observation may lead to the conclusion that experience with splenic cysts is still limited and, thus, currently available guidelines and treatment algorithms may be updated and reformed, as more recent findings, including our own, may gradually challenge the clinical concepts applied so far, suggesting that the patient's symptomatology and the cyst location and not the size alone should be the main criteria considered for surgical treatment of a true splenic cyst, since it is obvious that an enlarged cyst will cause analogous symptoms. The clinical outcome of a cyst independent of the size that causes mild symptoms is not easy to predict and observation could be the golden standard.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
The authors state that there was no extra-institutional funding. Nikolaos Ekonomopoulos and Nikolaos Kalamakis were major contributors in composing the manuscript.
- Giovagnoni A, Chiara G, Goteri G: Tumours of the spleen. Cancer Imag. 2005, 5: 73-77. 10.1102/1470-7330.2005.0002.View ArticleGoogle Scholar
- Morgenstern L: Nonparasitic splenic cysts: pathogenesis, classification and treatment. J Am Coll Surg. 2002, 194: 306-314. 10.1016/S1072-7515(01)01178-4.View ArticlePubMedGoogle Scholar
- Cowles RA, Yahanda AM: Epidermoid cyst of the spleen. Am J Surg. 2000, 180: 227-10.1016/S0002-9610(00)00446-3.View ArticlePubMedGoogle Scholar
- Yigitbasi R, Karabicak I, Aydogan F, Erturk S, Bican O, Aydin O, Kantarci F: Benign splenic epithelial cyst accompanied by elevated Ca 19-9 level: a case report. Mt Sinai J Med. 2006, 73: 871-873.PubMedGoogle Scholar
- Macheras A, Misiakos E, Liakakos T, Mpistarakis D, Fotiadis C, Karatzas G: Non-parasitic splenic cysts: a report of three cases. World J Gastrenterol. 2005, 11: 6884-6887.View ArticleGoogle Scholar
- Mertens J, Penninckx F, DeWever I, Topal B: Long-term outcome after surgical treatment of nonparasitic splenic cysts. Surg Endosc. 2007, 21: 206-208. 10.1007/s00464-005-0039-3.View ArticlePubMedGoogle Scholar
- Alkofer B, Lepennec V, Chiche L: Splenic cysts and tumors: diagnosis and management. J Chir. 2005, 142: 6-13. 10.1016/S0021-7697(05)80830-0.View ArticleGoogle Scholar
- Hansen M, Moller A: Splenic cysts. Surg Laparosc Endosc Percutan Tech. 2004, 14: 316-322. 10.1097/01.sle.0000148463.24028.0c.View ArticlePubMedGoogle Scholar
- Gianom D, Wildisen A, Hotz T, Goti F, Decurtins M: Open and laparoscopic treatment of nonparasitic splenic cysts. Dig Surg. 2003, 20: 74-78. 10.1159/000068860.View ArticlePubMedGoogle Scholar
- Mirilas P, Demetriades DM, Siatitsas YS: Epithelial (epidermoid) splenic cysts in childhood: surgical management of eight cases. Am Surg. 2002, 68: 134-138.PubMedGoogle Scholar
- Yagi S, Isaji S, Iida T, Mizuno S, Tabata M, Yamagiwa K, Yokoi H, Imai H, Uemoto S: Laparoscopic splenectomy for a huge splenic cyst without preoperative drainage: report of a case. Surg Laparosc Endosc Percutan Tech. 2003, 13: 397-400. 10.1097/00129689-200312000-00012.View ArticlePubMedGoogle Scholar
- Ganti AL, Sardi A, Gordon J: Laparoscopic treatment of large true cysts of the liver and spleen is ineffective. Am Surg. 2002, 68: 1012-1017.PubMedGoogle Scholar
- Kaiwa Y, Kurokawa Y, Namiki K, Matsumoto H, Satomi S: Laparoscopic partial splenectomies for true splenic cysts: a report of two cases. Surg Endosc. 2000, 14: 865.View ArticlePubMedGoogle Scholar
- Till H, Schaarschmidt K: Partial laparoscopic decapsulation of congenital splenic cysts. Surg Endosc. 2004, 18: 626-628. 10.1007/s00464-003-9046-4.View ArticlePubMedGoogle Scholar
- Tagaya N, Oda N, Furihata M, Nemoto T, Suzuki N, Kubota K: Experience with laparoscopic management of solitary symptomatic splenic cyts. Surg Laparosc Endosc Percutan Tech. 2002, 12: 279-282. 10.1097/00129689-200208000-00016.View ArticlePubMedGoogle Scholar
- Smith ST, Scott DJ, Burdick JS, Rege RV, Jones DB: Laparoscopic marsupialization and hemisplenectomy for splenic cysts. J Laparoendosc Adv Surg Tech. 2001, 11: 243-249. 10.1089/109264201750539781.View ArticleGoogle Scholar
- Saada J, Parant O, Kessler S, Aziza J, Sarramon M: Prenatal diagnosis and outcome of congenital splenic cyst: report of two cases. Prenat Diagn. 2006, 26: 9-10. 10.1002/pd.1314.View ArticlePubMedGoogle Scholar
- Lopes M, Ruano R, Bunduki V, Miyadahira S, Zugaib M: Prenatal diagnosis and follow up of congenital splenic cyst: a case report. Ultrasound Obstet Gynecol. 2001, 17: 439-441. 10.1046/j.1469-0705.2001.00401.x.View ArticlePubMedGoogle Scholar
- Chen IL, Tsai CC, Yang SN, Liu CA, Hsu TY, Huang HC: Spontaneous regression of congenital splenic cyst in a neonate. Clin Pediatr. 2007, 46: 73-75. 10.1177/0009922806289045.View ArticleGoogle Scholar
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