- Case Report
- Open Access
Tumor-like pulmonary sarcoidosis diagnosed by CT-guided transthoracic lung biopsy
Cases Journalvolume 2, Article number: 6607 (2009)
Most patients referred for lung biopsy have a focal lesion that is likely to be a carcinoma and fine needle aspiration (FNA) is usually sufficient to confirm diagnosis. Percutaneous cutting needle biopsy (CNB) is an important and potential diagnostic technique when non carcinomatous disease is suspected or when the pulmonary disease is unclear, so tissue architecture is very important.
We present a case of a 24 year old male arrived at our hospital with dyspnea and unusual computed tomography (CT) findings of sarcoidosis. Chest X-ray and CT scan revealed multiple masses in both lungs suggesting lung metastasis. Bronchoscopy and bronchoalveolar lavage did not reveal any malignant cells. None of the laboratory examinations revealed any primary extrapulmonary tumor. The patient underwent CT-guided core needle biopsy. Histopathological examination confirmed the diagnosis of sarcoidosis.
CT-guided core needle biopsy is a very helpful diagnostic tool in order to determine the benign or malignant nature of a thoracic lesion.
Complication rates are of 29-45% .
However it is much less successful in the diagnosis of benign focal lesions, diffuse lung disease (DLD), or when the pulmonary disease is unclear, in which case tissue architecture is important -.
CNB on the other side, provides cores of tissue for histological evaluation, although the American Thoracic Society Guidelines have stated that CNB should not be used in the diagnosis of DLD .
However it is an increasing safe procedure in the determination of malignant and non-malignant lesions.
The alternatives to percutaneous biopsy include open biopsy, video-assisted thoracoscopic biopsy and transbronchial biopsy. All of these however require general anesthesia.
A 24-year old male (of greek origin and nationality) presented to our hospital complaining dyspnea.
He underwent a chest X-ray that revealed multiple bilateral pulmonary masses.
The patient underwent a chest CT scan (Siemens, Somatom Emotion Duo, spiral tomography, 5 mm slice thickness, mediastinal and pulmonary window), that revealed well circumscribed multiple round masses, involving both lungs, suggesting lung metastasis and enlarged mediastinal lymph nodes (fig. 1,2).
Further imaging exams were performed (abdominal CT scan), which excluded any primary extrapulmonary tumor. The patient underwent other laboratory exams (blood tests) which had negative results.
The patient therefore underwent a CT-guided core biopsy using a 18 gauge (G) cutting needle (Somatex, medical technologies, GmbH, 18 G, 100 mm length).
The method was performed under local anesthesia.
The patient was placed in the appropriate position considering the location of the lesion.
Using a spiral CT, 5 mm slices were taken in order to specify the exact skin entry point, for the needle insertion.
The puncture point was prepared in a sterile fashion and then a 20 G needle was inserted.
A few CT images were taken to ensure that the chosen point of entry was the appropriate. Then, local anesthetic (20 cc) 2% lydocaine (xylocaine) was instilled. After that, a 18 G and 10 mm long cutting needle was inserted (fig. 3).
The distance between the skin and the edge of the lesion was calculated from a relevant CT image. 1-3 specimens were prelevated from the lesion, which were then put in formalin for histological examination.
The procedure was successful.
No complications occurred.
Histopathological examination confirmed the diagnosis of stage II sarcoidosis. It revealed multiple epitelioid cell granulomas with giant cells, in the absence of microbiological or virological abnormalities.
The first lung core-needle biopsies were reported by Dutra and Geraci in 1954  after Silverman introduced the cutting needle in 1938.
In 1989 the American Thoracic Society Guidelines stated that CNB remained much less sensitive than open biopsy in the diagnosis of DLD with a sensitivity of 53-94%.
The automatic cutting needle biopsy devices introduced over the last few decades, appear to be safer than the older needles.
Complication rates in recent series are 15-33%.
Specificity of the CNB is 100%.
Sarcoidosis is a disease of unknown etiology characterized by non-necrotizing granulomatous inflammation involving one or more organs.
Estimates vary, but between 20 to 40% of patients present asymptomatic bilateral hilar lymphadenopathy . In the remainder, a variety of tissues may be affected and mass lesions may result.
Tests formerly believed to be diagnostic of sarcoidosis, have proven to be non-specific.
These include serum ACE, which can be elevated in a variety of granulomatous diseases and BAL fluid analysis .
The Kwiem-Stilzbach skin test, although highly specific, is not standardized and is not widely available.
In patients who present findings uncharacteristic of sarcoidosis, such as isolated superficial and/or deep parenchymal nodules or masses and no previous clinical history that suggest the diagnosis, tissue diagnosis is necessary.
Core needle biopsy under CT guidance, is a very helpful, minimally invasive technique in the determination of malignant and non malignant lesions, with a few associated complications.
We showed successfully the usefulness of the method in the diagnosis of sarcoidosis with unusual CT scan findings.
"Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal."
Sidiropoulou N.: description of case, description of case, review of bibliography. Filippousis P.: responsible of discussion part. Apostolopoulou S.: description of case. Tsangaridou I.: responsible of figure selection. Thanos L.: supervision of the hole case report.
angiotensin converting enzyme
core needle biopsy
diffuse lung disease
fine needle biopsy
high resolution computed tomography.
Boiselle PM, Shepard J-AO, Mark EJ, Szyfelbein WM, Fan C-M, Slanetz PJ, et al: Routine addition of an automated biopsy device to fine needle aspiration of the lung; a prospective assessment. AJR. 1997, 169: 661-666.
Stanley JH, Fish GD, Andriole JG, Gobien RP, Betsill WL, Laden SA, et al: Lung lesions: cytologic diagnosis by fine needle biopsy. Radiology. 1987, 162: 389-391.
Arakawa H, Nakajima Y, Kurihara Y, Niimi H, Ishikawa T: CT-guided transthracic needle biopsy: a comparison between automated biopsy gun and fine needle aspiration. Clinic Radiology. 1996, 51: 503-506. 10.1016/S0009-9260(96)80191-7.
Goralnic CH, O'Connel DM, El Yousef SJ, Haaga JR: CT-guided cutting needle biopsies of selected chest lesions. AJR. 1998, 151: 903-907.
Klein JS, Salomon G, Stewart EA: Transthoracic needle biopsy with a coaxially placed 20-G automated cutting needle: results in 122 patients. Radiology. 1996, 198: 715-720.
Sokolowski JW, Burger LW, Jones FL, Patterson JR, Selecky PA: American Thoracic Society Guidelines of percutaneous transthoracic needle biopsy. Am Rev Resp Dis. 1989, 140: 255-256.
Dutra FR, Geraci CL: Needle biopsy of the lung. JAMA. 1954, 155: 21-24.
Zavala DC, Bedell GN: Percutaneous lung biopsy with a cutting needle: an analysis of 40 cases and comparison with other biopsy techniques. Am Rev Resp Dis. 1972, 106: 186-193.
Youmans CR, de Groot WJ, Marshall R, Morettin LB, Derrick JR: Needle biopsy of the lung in diffuse parenchimal disease: an analysis of 151 cases. Ann J Surg. 1970, 120: 637-643. 10.1016/S0002-9610(70)80184-2.
Meyer JE, Ferrucci JT, Janower ML: Fatal complications of percutaneous lung biopsy: review of the literature and report of a case. Radiology. 1970, 96: 47-48.
Norenberg R, Claxton CP, Takaro T: Percutaneous needle biopsy of the lung: report of two fatal complications. Chest. 1974, 66: 216-218. 10.1378/chest.66.2.216.
Lohela P, Tikkakosi T, Ammala K, Strengell L, Suramo I, Repo UK: Diagnosis of diffuse lung disease by cutting needle biopsy. Acta Radiol. 1994, 35: 251-254. 10.3109/02841859409172377.
Nidem AH, Salem F: A Safe high-yield technique for cutting needle biopsy of the lung in patients with DLD. Chest. 1997, 111: 1615-1621. 10.1378/chest.111.6.1615.
Peckham DG, Spiteri MA: Sarcoidosis. Postgrad Med J. 1996, 72: 196-200. 10.1136/pgmj.72.846.196.
Moller DR: Etiology of sarcoidosis. Clin Chest Med. 1997, 18: 695-706. 10.1016/S0272-5231(05)70413-5.
"The authors declare that they have no competing interests".